RhoA/Rho-kinase and vascular diseases: what is the link?

被引：0

作者：

Kenia Pedrosa Nunes

Christine S. Rigsby

R. Clinton Webb

机构：

[1] Medical College of Georgia,Department of Physiology, CA3101, School of Medicine

来源：

Cellular and Molecular Life Sciences | 2010年 / 67卷

关键词：

RhoA; Rho-kinase; Cardiovascular diseases; Diabetes; Pulmonary hypertension; Erectile dysfunction; Cancer;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

RhoA/Rho-kinase pathway plays an important role in many pathological conditions. RhoA participates in the regulation of smooth muscle tone and activates many downstream kinases. The best characterized are the serine/threonine kinase isoforms (Rho-kinase or ROCK), ROCKα/ROCK2 and ROCKβ/ROCK1. ROCK is necessary for diverse functions such as local blood flow, arterial/pulmonary blood pressure, airway resistance and intestinal peristalsis. ROCK activation permits actin/myosin interactions and smooth muscle cells contraction by maintaining the activity of myosin light-chain kinase, independently of the free cytosolic calcium level. The sensitization of smooth muscle myofilaments to calcium has been implicated in many pathological states, such as hypertension, diabetes, heart attack, stroke, pulmonary hypertension, erectile dysfunction, and cancer. The focus of this review is on the involvement of RhoA/Rho-kinase in diseases. We will briefly describe the ROCK isoforms and the role of RhoA/Rho-kinase in the vasculature, before exploring the most recent findings regarding this pathway and various diseases.

引用

页码：3823 / 3836

页数：13

共 50 条

[31] HMC05 attenuates vascular contraction through inhibition of RhoA/Rho-kinase signaling pathway
Kim, InKyeom
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115 : 211P - 211P
[32] Role of the RhoA/Rho-kinase pathway in the regulation of pulmonary vasoconstrictor function
Nossaman, Bobby D.
Nossaman, Vaughn E.
Murthy, Subramanyam N.
Kadowitz, Philip J.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2010, 88 (01) : 1 - 8
[33] DOES CHRONIC BLADDER ISCHEMIA AFFECT RHOA/RHO-KINASE PATHWAY?
Akaihata, H.
Nomiya, M.
Takahashi, N.
Haga, N.
Ogawa, S.
Sato, Y.
Koguchi, T.
Aikawa, K.
Kojima, Y.
NEUROUROLOGY AND URODYNAMICS, 2013, 32 (06) : 840 - 841
[34] Signal transduction through the RhoA/Rho-kinase pathway in smooth muscle
Somlyo, AP
Somlyo, AV
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 2004, 25 (08) : 613 - 615
[35] RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insights
Jin, LM
Burnett, AL
CLINICAL SCIENCE, 2006, 110 (02) : 153 - 165
[36] Rho/Rho-kinase as a novel therapeutic target in the treatment of cardiovascular diseases
Goto, D
Fujii, S
Kitabatake, A
DRUGS OF THE FUTURE, 2003, 28 (03) : 267 - 271
[37] Vascular hypocontractility of cirrhotic rats is associated with impaired membrane-translocation of RhoA and blunted activation of Rho-kinase
Hennenberg, M
Trebicka, J
Sauerbruch, T
Heller, J
HEPATOLOGY, 2005, 42 (04) : 417A - 417A
[38] Honokiol attenuates vascular contraction through the inhibition of the RhoA/Rho-kinase signalling pathway in rat aortic rings
Seok, Young Mi
Cho, Hae Joung
Cha, Byung-Yoon
Woo, Je-Tae
Kim, In Kyeom
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, 63 (09) : 1244 - 1251
[39] Role of Rho-kinase in vascular abnormalities associated with obesity
Wakino, Shu
Sugano, Naoki
Homma, Koichiro
Yoshioka, Kyoko
Hasegawa, Kazuhiro
Tatematsu, Satoru
Saruta, Takao
Hayashi, Koichi
JOURNAL OF HYPERTENSION, 2006, 24 : 193 - 193
[40] Involvement of Rho-kinase in experimental vascular endothelial dysfunction
Shah, DI
Singh, M
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2006, 283 (1-2) : 191 - 199

← 1 2 3 4 5 →