Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside

被引：69

作者：

Grusch M. ^{[1
]}

Polgar D. ^{[1
]}

Gfatter S. ^{[2
]}

Leuhuber K. ^{[3
]}

Huettenbrenner S. ^{[1
]}

Leisser C. ^{[1
]}

Fuhrmann G. ^{[1
]}

Kassie F. ^{[2
]}

Steinkellner H. ^{[2
]}

Smid K. ^{[4
]}

Peters G.J. ^{[4
]}

Jayaram H.N. ^{[5
]}

Klepal W. ^{[3
]}

Szekeres T. ^{[6
]}

Knasmuüller S. ^{[2
]}

Krupitza G. ^{[1
]}

机构：

[1] Institute of Clinical Pathology, University of Vienna

[2] Institute for Cancer Research, University of Vienna

[3] Institute of Zoology, University of Vienna

[4] Department of Medical Oncology, University Hospital VU Amsterdam

[5] Department of Biochemistry and Molecular Biology and Laboratory for Experimental Oncology, Indiana University School of Medicine, Indianapolis

[6] Clinical Institute of Medical and Chemical Laboratory Diagnosis, University of Vienna

来源：

Cell Death & Differentiation | 2002年 / 9卷 / 2期

关键词：

Apoptosis; ATP; Benzamide riboside; Necrosis;

D O I：

10.1038/sj.cdd.4400937

中图分类号：

学科分类号：

摘要：

A new synthetic drug, benzamide riboside (BR) exhibited strong oncolytic activity against leukemic cells in the 5-10 μM range. Higher BR-concentrations (20 μM) predominantly induced necrosis which correlated with DNA strand breaks and subsequent depletion of ATP- and dATP levels. Replenishment of the ATP pool by addition of adenosine prevented necrosis and favoured apoptosis. This effect was not a pecularity of BR-treatment, but was reproduced with high concentrations of all trans-retinoic acid (120 μM) and cyanide (20 mM). Glucose was also capable to suppress necrosis and to favour apoptosis of HL-60 cells, which had been treated with necrotic doses of BR and cyanide. Apoptosis eliminates unwanted cells without affecting the microenvironment, whereas necrosis causes severe inflammation of surrounding tissues due to spillage of cell fluids into the peri-cellular space. Thus, the monitoring and maintenance of cellular energy pools during therapeutic drug treatment may help to minimize nonspecific side effects and to improve attempted drug effects.

引用

页码：169 / 178

页数：9

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