Gene signatures from pancreatic cancer tumor and stromal cells predict disease outcome

被引：0

作者：

Filippos Kottakis

Nabeel Bardeesy

机构：

[1] Filippos Kottakis and Nabeel Bardeesy are at the Center for Cancer Research,and the Department of Medicine

[2] Massachusetts General Hospital,undefined

[3] Boston,undefined

[4] Massachusetts,undefined

[5] USA,undefined

[6] the Center for Regenerative Medicine,undefined

[7] Massachusetts General Hospital,undefined

[8] Boston,undefined

[9] Massachusetts,undefined

[10] USA,undefined

[11] Harvard Medical School,undefined

[12] Boston,undefined

[13] Massachusetts,undefined

[14] USA.,undefined

来源：

Nature Genetics | 2015年 / 47卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Pancreatic cancers consist of a heterogeneous amalgam of assorted cell types, making it challenging to develop a classification system that groups these tumors according to common molecular features. A new study tackles this important issue using bioinformatics approaches to decipher gene expression signatures derived specifically from either tumor cells or nonmalignant stromal cells that predict patient outcome and may inform personalized treatments.

引用

页码：1102 / 1103

页数：1

共 50 条

[11] Prognostic stromal gene signatures in breast cancer
Sofia Winslow
Karin Leandersson
Anders Edsjö
Christer Larsson
Breast Cancer Research, 17
[12] Prognostic stromal gene signatures in breast cancer
Winslow, Sofia
Leandersson, Karin
Edsjo, Anders
Larsson, Christer
BREAST CANCER RESEARCH, 2015, 17
[13] Immune cells and signatures characterize tumor microenvironment and predict outcome in ovarian and endometrial cancers
Ni, Ying
Soliman, Ahmed
Joehlin-Price, Amy
Abdul-Karim, Fadi
Rose, Peter G.
Mahdi, Haider
IMMUNOTHERAPY, 2021, 13 (14) : 1179 - 1192
[14] Serum protein profiling to predict disease burden and outcome in pancreatic cancer
Carpizo, D. R.
Qin, L. X.
Brennan, M. F.
Lokshin, A.
Allen, P. J.
ANNALS OF SURGICAL ONCOLOGY, 2008, 15 : 88 - 88
[15] Gene expression signatures may predict clinical outcome
Speirs V.
Breast Cancer Research, 4 (1)
[16] The outcome of inhibition of stromal TGFβRII in pancreatic cancer is tumor cell-dependent
Ostapoff, Katherine T.
Cenik, Bercin K.
Carroll, Kyla
Brekken, Rolf A.
CANCER RESEARCH, 2012, 72
[17] In Silico Ascription of Gene Expression Differences to Tumor and Stromal Cells in a Model to Study Impact on Breast Cancer Outcome
Myhre, Simen
Mohammed, Hayat
Tramm, Trine
Alsner, Jan
Finak, Greg
Park, Morag
Overgaard, Jens
Borresen-Dale, Anne-Lise
Frigessi, Arnoldo
Sorlie, Therese
PLOS ONE, 2010, 5 (11):
[18] Tumor-stromal interactions in pancreatic cancer
Tod, Jo
Jenei, Veronika
Thomas, Gareth
Fine, David
PANCREATOLOGY, 2013, 13 (01) : 1 - 7
[19] Stromal expression of suicide gene FCU1 affects proliferation of tumor cells and depletes stromal cells in co-culture models of pancreatic cancer
Kopantseva, Marina
Usova, Eugenia
Kostina, Maria
Melekhina, Olga
Egorov, Vyacheslav
Kopantzev, Eugene P.
Sverdlov, Eugene D.
CANCER RESEARCH, 2014, 74 (19)
[20] Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions
Ohuchida, K
Mizumoto, K
Murakami, M
Qian, LW
Sato, N
Nagai, E
Matsumoto, K
Nakamura, T
Tanaka, M
CANCER RESEARCH, 2004, 64 (09) : 3215 - 3222

← 1 2 3 4 5 →