Targeted Therapy in Gliomas

被引：0
|
作者：
Mohamed Ali Hamza
Mark Gilbert
机构：
[1] The University of Texas MD Anderson Cancer Center,
来源：
Current Oncology Reports | 2014年 / 16卷
关键词：
Malignant gliomas; Gliomas; Radiation therapy; Chemotherapeutic agents; Oncology; Neuro-oncology; Molecular targets; Glioma patients; Central nervous system (CNS); Flioblastoma (GBM); Anaplastic gliomas; Therapeutic agents;
D O I：
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学科分类号：
摘要：
The survival outcome of patients with malignant gliomas is still poor, despite advances in surgical techniques, radiation therapy and the development of novel chemotherapeutic agents. The heterogeneity of molecular alterations in signaling pathways involved in the pathogenesis of these tumors contributes significantly to their resistance to treatment. Several molecular targets for therapy have been discovered over the last several years. Therapeutic agents targeting these signaling pathways may provide more effective treatments and may improve survival. This review summarizes the important molecular therapeutic targets and the outcome of published clinical trials involving targeted therapeutic agents in glioma patients.
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