Complex 69mZnLigCl2 (Lig is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide) as a potential radiopharmaceutical

被引：0
|
作者：
M. A. Orlova
T. P. Trofimova
A. P. Orlov
I. A. Ivanov
A. V. Severin
G. Yu. Aleshin
S. S. Belyshev
A. N. Vasiliev
S. N. Kalmykov
机构：
[1] M. V. Lomonosov Moscow State University,Chemical Department
[2] Dmitry Rogachev National Medical Scientific Center of Pediatric Hematology,Institute of Physiologically Active Compounds
[3] Oncology,D. V. Skobel’tsyn Research Institute of Nuclear Physics
[4] and Immunology,undefined
[5] Russian Academy of Sciences,undefined
[6] M. V. Lomonosov Moscow State University,undefined
[7] National Research Center “Kurchatov Institute,undefined
[8] ”,undefined
来源：
Russian Chemical Bulletin | 2018年 / 67卷
关键词：
Zn isotope; dihydrothiazine derivatives; hydroxyapatite; K-562;
D O I：
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学科分类号：
摘要：
The cytotoxicity of complex 69mZnLigCl2 (Lig is N-(5,6-dihydro-4H-1,3-thiazin-2-yl) benzamide) against the K-562 cell line (chronic myeloid leukemia) was considered in comparison with the cells of healthy donors. The 69mZnLigCl2 complex was obtained and characterized by TLC and autoradiography methods. The kinetics of zinc sorption on hydroxyapatite was studied.
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页码：774 / 778
页数：4
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