Poly-gamma-glutamic acid from Bacillus subtilis upregulates pro-inflammatory cytokines while inhibiting NLRP3, NLRC4 and AIM2 inflammasome activation

被引：0

作者：

Huijeong Ahn

Seung Goo Kang

Sung-il Yoon

Pyeung-Hyeun Kim

Doo Kim

Geun-Shik Lee

机构：

[1] College of Veterinary Medicine and Institute of Veterinary Science,Department of Systems Immunology

[2] Kangwon National University,Department of Molecular Bioscience

[3] College of Biomedical Science,undefined

[4] Kangwon National University,undefined

[5] School of Biomedical Science,undefined

[6] Kangwon National University,undefined

来源：

Cellular & Molecular Immunology | 2018年 / 15卷

关键词：

cytokines; inflammasome; macrophages; poly-gamma-glutamate;

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摘要：

Poly-gamma-glutamic acid (γ-PGA) is a natural, edible and non-toxic polymer synthesized by Bacillus subtilis and is suggested as a safe biomaterial for the use in hydrogels and vaccine adjuvants. However, the effect of γ-PGA on inflammasome activation has not yet been studied in macrophages. Inflammasomes, which are intracellular multi-protein complexes, promote acute and chronic inflammation via interleukin-1β or interleukin-18 maturation, and they are known targets for metabolic syndromes and cancer. In this study, we observed that γ-PGA attenuated NLRP3, NLRC4 and AIM2 inflammasome activation, whereas it upregulated pro-inflammatory cytokine expression in human and murine macrophages. Although γ-PGA had conflicting effects on cytokine production and maturation, it clearly alleviated the severity of lipopolysaccharide-induced endotoxin shock in an animal model. Thus, we suggest γ-PGA as a candidate to control inflammasome-mediated disorders.

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页码：111 / 119

页数：8