Hypothyroidism in hibernating brown bears

被引:0
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作者
Anne Mette Frøbert
Claus G. Nielsen
Malene Brohus
Jonas Kindberg
Ole Fröbert
Michael T. Overgaard
机构
[1] Aalborg University,Department of Chemistry and Bioscience, Faculty of Engineering and Science
[2] Aalborg University Hospital,Department of Clinical Biochemistry
[3] Swedish University of Agricultural Sciences,Department of Wildlife, Fish and Environmental Studies
[4] Norwegian Institute for Nature Research,Steno Diabetes Center Aarhus
[5] Aarhus University Hospital,Department of Cardiology, Faculty of Health
[6] Örebro University,Department of Clinical Medicine, Faculty of Health
[7] Aarhus University,Department of Clinical Pharmacology
[8] Aarhus University Hospital,undefined
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关键词
Thyroid hormone; Thyroxine; Triiodothyronine; Thyroxine-binding globulin (TBG); Hibernation; Hypothyroidism; Metabolism;
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摘要
Brown bears hibernate throughout half of the year as a survival strategy to reduce energy consumption during prolonged periods with scarcity of food and water. Thyroid hormones are the major endocrine regulators of basal metabolic rate in humans. Therefore, we aimed to determine regulations in serum thyroid hormone levels in hibernation compared to the active state to investigate if these are involved in the adaptions for hibernation.
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