Butyrylcholinesterase K variant and Alzheimer’s disease

被引：0
|
作者：
P. K. Panegyres
Cyril D. S. Mamotte
Sam D. Vasikaran
Steve Wilton
Vicki Fabian
Byron A. Kakulas
机构：
[1] Department of Neuropathology,
[2] Royal Perth Hospital,undefined
[3] Wellington Street,undefined
[4] AUS-Perth 6000,undefined
[5] Australia Fax: +618-92242556,undefined
[6] Department of Clinical Biochemistry,undefined
[7] Royal Perth Hospital,undefined
[8] Wellington Street,undefined
[9] AUS-Perth 6000,undefined
[10] Australia,undefined
[11] Australian Neuromuscular Research Institute,undefined
[12] AUS-Perth 6000,undefined
[13] Australia,undefined
来源：
Journal of Neurology | 1999年 / 246卷
关键词：
Key words Dementia; Genotyping; APOE;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study attempted to corroborate findings on the association between butyrylcholinesterase K variant and Alzheimer’s disease. This was performed on an autopsy-confirmed series of patients with Alzheimer’s disease and controls. The butyrylcholinesterase K variant was found to be of increased allele frequency in patients with sporadic Alzheimer’s disease. When related to APOE ɛ4 typing the association was specific but not sensitive for the diagnosis of Alzheimer’s disease.
引用
收藏
页码：369 / 370
页数：1
相关论文
共 50 条
  • [21] Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease
    Lehman, DJ
    Nagy, Z
    Litchfield, S
    Borja, MC
    Smith, AD
    [J]. HUMAN GENETICS, 2000, 106 (04) : 447 - 452
  • [22] Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease
    Donald J. Lehmann
    Zsuzsanna Nagy
    Suzanne Litchfield
    Mario Cortina Borja
    A. David Smith
    [J]. Human Genetics, 2000, 106 : 447 - 452
  • [23] Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease
    Lehmann, DJ
    Johnston, C
    Smith, AD
    [J]. HUMAN MOLECULAR GENETICS, 1997, 6 (11) : 1933 - 1936
  • [24] Synergistic effect of apolipoprotein E ε4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease
    Lane, Roger
    Feldman, Howard H.
    Meyer, Joanne
    He, Yunsheng
    Ferris, Steven H.
    Nordberg, Agneta
    Darreh-Shori, Taher
    Soininen, Hilkka
    Pirttila, Tuula
    Farlow, Martin R.
    Sfikas, Nikolaos
    Ballard, Clive
    Greig, Nigel H.
    [J]. PHARMACOGENETICS AND GENOMICS, 2008, 18 (04): : 289 - 298
  • [25] Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease
    Darvesh, Sultan
    [J]. CURRENT ALZHEIMER RESEARCH, 2016, 13 (10) : 1173 - 1177
  • [26] Butyrylcholinesterase radioligands to image Alzheimer's disease brain
    Darvesh, Sultan
    [J]. CHEMICO-BIOLOGICAL INTERACTIONS, 2013, 203 (01) : 354 - 357
  • [27] Butyrylcholinesterase: a target in the cholinergic treatment of Alzheimer's disease
    Potkin, SG
    [J]. PRIMARY CARE PSYCHIATRY, 2004, 9 (03): : 83 - 87
  • [28] Acetylcholinesterase and butyrylcholinesterase glycoforms are biomarkers of Alzheimer's disease
    Saez-Valero, Javier
    Small, David H.
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2001, 3 (03) : 323 - 328
  • [29] Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation
    Holmes, C
    Ballard, C
    Lehmann, D
    Smith, AD
    Beaumont, H
    Day, IN
    Khan, MN
    Lovestone, S
    McCulley, M
    Morris, CM
    Munoz, DG
    O'Brien, K
    Russ, C
    Del Ser, T
    Warden, D
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2005, 76 (05): : 640 - 643
  • [30] Butyrylcholinesterase, cholinergic neurotransmission and the pathology of Alzheimer's disease
    Geula, C
    Darvesh, S
    [J]. DRUGS OF TODAY, 2004, 40 (08) : 711 - 721
12345