Dexmedetomidine inhibits Tetrodotoxin-resistant Nav1.8 sodium channel activity through Gi/o-dependent pathway in rat dorsal root ganglion neurons

被引：0
|
作者：
Xi-Yao Gu
Ben-Long Liu
Kai-Kai Zang
Liu Yang
Hua Xu
Hai-Li Pan
Zhi-Qi Zhao
Yu-Qiu Zhang
机构：
[1] Fudan University,Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science
[2] The Second Military Medical University,Department of Anesthesiology, Changhai Hospital
[3] Nanchang University,Center for Neuropsychiatric Diseases, Institute of Life Science
来源：
Molecular Brain | / 8卷
关键词：
α2-adrenoceptor; Dexmedetomidine; Dorsal root ganglion; Pain; Tetrodotoxin-resistant (TTX-R) sodium channel Na; 1.8; Whole-cell recording;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] A comparison of the effects of veratridine on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in isolated rat dorsal root ganglion neurons
    Farrag, K. J.
    Bhattacharjee, A.
    Docherty, R. J.
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2008, 455 (05): : 929 - 938
  • [22] DIFFERENTIAL PROPERTIES OF TETRODOTOXIN-SENSITIVE AND TETRODOTOXIN-RESISTANT SODIUM-CHANNELS IN RAT DORSAL-ROOT GANGLION NEURONS
    ROY, ML
    NARAHASHI, T
    JOURNAL OF NEUROSCIENCE, 1992, 12 (06): : 2104 - 2111
  • [23] A comparison of the effects of veratridine on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in isolated rat dorsal root ganglion neurons
    K. J. Farrag
    A. Bhattacharjee
    R. J. Docherty
    Pflügers Archiv - European Journal of Physiology, 2008, 455 : 929 - 938
  • [24] Intrathecal antisense oligonucleotide against the tetrodotoxin-resistant sodium channel (Nav1.8) reduces bladder hyperactivity in the spontaneously hypertensive rat.
    Lee, KS
    Dean-Mckinney, T
    Tuttle, JB
    Steers, WD
    JOURNAL OF UROLOGY, 2002, 167 (04): : 38 - 38
  • [25] Tetrodotoxin-resistant sodium channels of dorsal root ganglion neurons are readily activated in diabetic rats
    Hirade, M
    Yasuda, H
    Omatsu-Kanbe, M
    Kikkawa, R
    Kitasato, H
    NEUROSCIENCE, 1999, 90 (03) : 933 - 939
  • [26] Properties of wild-type and fluorescent protein-tagged mouse tetrodotoxin-resistant sodium channel (NaV1.8) heterologously expressed in rat sympathetic neurons
    Schofield, Geoffrey G.
    Puhl, Henry L., III
    Ikeda, Stephen R.
    JOURNAL OF NEUROPHYSIOLOGY, 2008, 99 (04) : 1917 - 1927
  • [27] Modulation of tetrodotoxin-resistant sodium channels by dihydropyrazole insecticide RH-3421 in rat dorsal root ganglion neurons
    Tsurubuchi, Y
    Zhao, XL
    Nagata, K
    Kono, Y
    Nishimura, K
    Yeh, JZ
    Narahashi, T
    NEUROTOXICOLOGY, 2001, 22 (06) : 743 - 753
  • [28] The tetrodotoxin-resistant Na+ channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice
    Roza, C
    Laird, JMA
    Souslova, V
    Wood, JN
    Cervero, F
    JOURNAL OF PHYSIOLOGY-LONDON, 2003, 550 (03): : 921 - 926
  • [29] PKCε-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons
    Cang, Chun-Lei
    Zhang, Hua
    Zhang, Yu-Qiu
    Zhao, Zhi-Qi
    MOLECULAR PAIN, 2009, 5
  • [30] Effects of Intrathecally Administerd NaV1.8 Antisense Oligonucleotide on the Expression of Sodium Channel mRNA in Dorsal Root Ganglion
    刘甬民
    姚尚龙
    宋文阁
    王月兰
    刘东
    曾涟
    华中科技大学学报(医学英德文版), 2005, (06) : 696 - 699
12345