Analyzing human epidermal growth factor receptor family dimerization and activation using Duolink®

被引：0
|
作者：
Mats Gullberg
Shan Huang
Ann-Catrin Andersson
机构：
[1] Mats Gullberg and Ann-Catrin Andersson are at Olink Bioscience,
来源：
Nature Methods | 2010年 / 7卷 / 12期
关键词：
D O I：
10.1038/nmeth.f.318
中图分类号：
学科分类号：
摘要：
Olink Bioscience has developed the Duolink® assay, which allows precise detection and quantification of proteins, protein interactions and modifications in fixed cells and tissue samples in their correct cellular context at physiologically relevant expression levels. This tool may ultimately be used in conjunction with new-generation anti-cancer therapies for inhibiting specific receptor dimerizations.
引用
收藏
页码：10 / 11
页数：1
相关论文
共 50 条
  • [21] The epidermal growth factor receptor family in breast cancer
    Koutras, Angelos K.
    Evans, T. R. Jeffry
    ONCOTARGETS AND THERAPY, 2008, 1 : 5 - 19
  • [22] Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface
    Dawson, JP
    Berger, MB
    Lin, CC
    Schlessinger, J
    Lemmon, MA
    Ferguson, KM
    MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (17) : 7734 - 7742
  • [23] Role of Epidermal Growth Factor Receptor and Src-Family Kinase Activation in Human Corneal Epithelial Wound Healing
    Bashir, Hasan Masud
    Maeno, Hiroshi
    Marshall, Christine
    Park, Claire Heesun
    Raju, Richu
    Seykora, John T.
    Lee, Vivian
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (12)
  • [24] Dynamical Rearrangement of Human Epidermal Growth Factor Receptor 2 upon Antibody Binding: Effects on the Dimerization
    Magalhaes, Pedro R.
    Machuqueiro, Miguel
    Almeida, Jose G.
    Melo, Andre
    Cordeiro, M. Natalia D. S.
    Verde, Sandra Cabo
    Gumus, Zeynep H.
    Moreira, Irina S.
    Correia, Joao D. G.
    Melo, Rita
    BIOMOLECULES, 2019, 9 (11)
  • [25] THE ROLE OF GLYCOSYLATION IN EPIDERMAL GROWTH FACTOR RECEPTOR ACTIVATION
    Zabczynska, Marta
    Opiola, Katarzyna
    Pochec, Ewa
    POSTEPY BIOLOGII KOMORKI, 2016, 43 (02) : 289 - 304
  • [26] Overexpression and activation of epidermal growth factor receptor in hemangioblastomas
    Chen, Gregory J.
    Karajannis, Matthias A.
    Newcomb, Elizabeth W.
    Zagzag, David
    JOURNAL OF NEURO-ONCOLOGY, 2010, 99 (02) : 195 - 200
  • [27] Epidermal growth factor receptor: mechanisms of activation and signalling
    Jorissen, RN
    Walker, F
    Pouliot, N
    Garrett, TPJ
    Ward, CW
    Burgess, AW
    EXPERIMENTAL CELL RESEARCH, 2003, 284 (01) : 31 - 53
  • [28] Overexpression and activation of epidermal growth factor receptor in hemangioblastomas
    Gregory J. Chen
    Matthias A. Karajannis
    Elizabeth W. Newcomb
    David Zagzag
    Journal of Neuro-Oncology, 2010, 99 : 195 - 200
  • [29] Transcriptional activation of the human epidermal growth factor receptor promoter by human p53
    LudesMeyers, JH
    Subler, MA
    Shivakumar, CV
    Munoz, RM
    Jiang, P
    Bigger, JE
    Brown, DR
    Deb, SP
    Deb, S
    MOLECULAR AND CELLULAR BIOLOGY, 1996, 16 (11) : 6009 - 6019
  • [30] Human Epidermal Growth Factor Receptor 2/Human Epidermal Growth Factor Receptor 3 PET Imaging Challenges and Opportunities
    Ducharme, Maxwell
    Mansur, Ameer
    Sligh, Luke
    Ulaner, Gary A.
    Lapi, Suzanne E.
    Sorace, Anna G.
    PET CLINICS, 2023, 18 (04) : 543 - 555
12345