Inhibition of NF-κB and the oxidative stress -dependent caspase-3 apoptotic pathway by betaine supplementation attenuates hepatic injury mediated by cisplatin in rats

被引：1

作者：

Hanan Hagar

Sufia Husain

Laila Mohamed Fadda

Nada M. Attia

Maher M. A. Attia

Hanaa Mahmoud Ali

机构：

[1] King Saud University,Pharmacology Unit, College of Medicine and King Khalid University Hospital

[2] Zagazig University,Department of Pharmacology and Toxicology, Pharmacy College

[3] King Saud University,Department of Pathology, College of Medicine and King Khalid University Hospital

[4] King Saud University,Department of Pharmacology, Faculty of Pharmacy

[5] Zagazig University,Medical College

[6] Zagazig University,Pharmacy College

[7] National Research Center,Department of Genetic and Cytology

[8] King Saud University,Common First Year Deanship

来源：

Pharmacological Reports | 2019年 / 71卷

关键词：

Cisplatin; Oxidative hepatic injury; Betaine; Caspase-3; Nuclear factor-kappa; Inflammation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

页码：1025 / 1033

页数：8

共 50 条

[31] Perfluorooctane sulphonate induces oxidative hepatic damage via mitochondria-dependent and NF-κB/TNF-α-mediated pathway
Han, Rui
Hu, Mingxian
Zhong, Qiang
Wan, Chong
Liu, Limin
Li, Fang
Zhang, Fang
Ding, Wenjun
CHEMOSPHERE, 2018, 191 : 1056 - 1064
[32] Curcumin prevents reperfusion injury following ischemic stroke in rats via inhibition of NF-κB, ICAM-1, MMP-9 and caspase-3 expression
Li, Wei
Suwanwela, Nijasri Charnnarong
Patumraj, Suthiluk
MOLECULAR MEDICINE REPORTS, 2017, 16 (04) : 4710 - 4720
[33] Vinpocetine reduces cisplatin-induced acute kidney injury through inhibition of NF-κB pathway and activation of Nrf2/ARE pathway in rats
Song, Wenjing
Yin, Weinan
Ding, Liang
Gao, Yang
Xu, JingJing
Yang, Yan
He, Xin
Gong, Pengju
Wei, Lei
Chen, Wenli
Zhang, Jingwei
INTERNATIONAL UROLOGY AND NEPHROLOGY, 2020, 52 (07) : 1389 - 1401
[34] NF-κB Mediated Anti-Apoptotic Signaling Limits the Tocolytic Action of Stretch Induced Uterine Caspase-3 Activity as Term Approaches.
Suresh, Arvind
Pancharatnam, Jeyasuria
Shynlova, Oksana
Lye, Stephen J.
Condon, Jennifer C.
REPRODUCTIVE SCIENCES, 2010, 17 (03) : 85A - 85A
[35] Tanshinone I Stimulates Pyroptosis of Cisplatin-Resistant Gastric Cancer Cells by Activating the NF-κB/Caspase-3(8)/GSDME Signaling Pathway
Wang, Guijun
Li, Yanrong
Guo, Zhaokai
He, Qiang
Liu, Zhen
Deng, Beibei
DNA AND CELL BIOLOGY, 2024, 43 (04) : 185 - 196
[36] Activation of a pro-apoptotic amplification loop through inhibition of NF-κB-dependent survival signals by caspase-mediated inactivation of RIP
Martinon, F
Holler, N
Richard, C
Tschopp, J
FEBS LETTERS, 2000, 468 (2-3) : 134 - 136
[37] Sacubitril/valsartan attenuates myocardial ischemia/reperfusion injury via inhibition of the GSK3β/NF-ΚB pathway in cardiomyocytes
Xiao, Fangping
Wang, Lei
Liu, Meng
Chen, Mingyue
He, Hao
Jia, Zhiqiang
Zhang, Lai
Yang, Yaqing
Hu, Qianfan
Hong, Mei
Zhang, Hanwen
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2022, 730
[38] Icariin attenuates cerebral ischemia-reperfusion injury through inhibition of inflammatory response mediated by NF-κB, PPARα and PPARγ in rats
Xiong, Deqing
Deng, Yuanyuan
Huang, Bin
Yin, Caixia
Liu, Bo
Shi, Jingshan
Gong, Qihai
INTERNATIONAL IMMUNOPHARMACOLOGY, 2016, 30 : 157 - 162
[39] Trimethylglycine (betaine) accentuates cisplatin-induced hepatotoxicity by suppressing oxidative stress and inflammation and down-regulation of nuclear factor kappa and caspase-3 in experimental rats
Hagar, H.
El Medany, A.
El Medany, G.
AMINO ACIDS, 2015, 47 (08) : 1685 - 1686
[40] Tranilast Treatment Attenuates Cerebral Ischemia-Reperfusion Injury in Rats Through the Inhibition of Inflammatory Responses Mediated by NF-κB and PPARs
Zhuo, Yue
Zhuo, Jun
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2019, 12 (02): : 196 - 202

← 1 2 3 4 5 →