Inhibition of NF-κB and the oxidative stress -dependent caspase-3 apoptotic pathway by betaine supplementation attenuates hepatic injury mediated by cisplatin in rats

被引:1
|
作者
Hanan Hagar
Sufia Husain
Laila Mohamed Fadda
Nada M. Attia
Maher M. A. Attia
Hanaa Mahmoud Ali
机构
[1] King Saud University,Pharmacology Unit, College of Medicine and King Khalid University Hospital
[2] Zagazig University,Department of Pharmacology and Toxicology, Pharmacy College
[3] King Saud University,Department of Pathology, College of Medicine and King Khalid University Hospital
[4] King Saud University,Department of Pharmacology, Faculty of Pharmacy
[5] Zagazig University,Medical College
[6] Zagazig University,Pharmacy College
[7] National Research Center,Department of Genetic and Cytology
[8] King Saud University,Common First Year Deanship
来源
Pharmacological Reports | 2019年 / 71卷
关键词
Cisplatin; Oxidative hepatic injury; Betaine; Caspase-3; Nuclear factor-kappa; Inflammation;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1025 / 1033
页数:8
相关论文
共 50 条
  • [1] Inhibition of NF-κB and the oxidative stress-dependent caspase-3 apoptotic pathway by betaine supplementation attenuates hepatic injury mediated by cisplatin in rats
    Hagar, Hanan
    Husain, Sufia
    Fadda, Laila Mohamed
    Attia, Nada M.
    Attia, Maher M. A.
    Ali, Hanaa Mahmoud
    PHARMACOLOGICAL REPORTS, 2019, 71 (06) : 1025 - 1033
  • [2] Honey protects against cisplatin-induced hepatic and renal toxicity through inhibition of NF-B-mediated COX-2 expression and the oxidative stress dependent BAX/Bcl-2/caspase-3 apoptotic pathway
    Neamatallah, Thikryat
    El-Shitany, Nagla A.
    Abbas, Aymn T.
    Ali, Soad S.
    Eid, Basma G.
    FOOD & FUNCTION, 2018, 9 (07) : 3743 - 3754
  • [3] Betaine supplementation protects against renal injury induced by cadmium intoxication in rats: Role of oxidative stress and caspase-3
    Hagar, Hanan
    Al Malki, Waleed
    ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2014, 37 (02) : 803 - 811
  • [4] Gliclazide attenuates cisplatin-induced nephrotoxicity through inhibiting NF-κB and caspase-3 activity
    Taghizadeh, Fatemeh
    Hosseinimehr, Seyed Jalal
    Zargari, Mehryar
    Karimpour Malekshah, Abbasali
    Talebpour Amiri, Fereshteh Beigom
    IUBMB LIFE, 2020, 72 (09) : 2024 - 2033
  • [5] Captopril downregulates expression of Bax/cytochrome C/caspase-3 apoptotic pathway, reduces inflammation, and oxidative stress in cisplatin-induced acute hepatic injury
    Eid, Basma G.
    El-Shitany, Nagla A.
    BIOMEDICINE & PHARMACOTHERAPY, 2021, 139
  • [6] Attenuation of sodium fluoride-induced hepatic injury by Lactobacillus casei through inhibition of NF-κβ signalling pathway with decreased expression of caspase-3 in rats
    Sedik, Ahmed A.
    Hassan, Soha A.
    EGYPTIAN JOURNAL OF CHEMISTRY, 2023, 66 (09): : 107 - 123
  • [7] Sinapic acid attenuates cyclophosphamide-induced liver toxicity in mice by modulating oxidative stress, NF-?B, and caspase-3
    Rezaei, Shiva
    Hosseinimehr, Seyed Jalal
    Zargari, Mehryar
    Malekshah, Abbasali Karimpour
    Mirzaei, Mansooreh
    Amiri, Fereshteh Talebpour
    IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2023, 26 (05) : 526 - 531
  • [8] Sophoricoside attenuates autoimmune-mediated liver injury through the regulation of oxidative stress and the NF-κB signaling pathway
    Chen, Yu
    Lei, Yu
    Wang, Han
    Wang, Lijia
    Xu, Jiaxin
    Wang, Shuhui
    Yu, Meiping
    Peng, Zhangqi
    Xiao, Fang
    Tian, Dean
    Liu, Mei
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023, 52 (03)
  • [9] Hyperoside attenuates neuroinflammation, cognitive impairment and oxidative stress via suppressing TNF-α/NF-κB/caspase-3 signaling in type 2 diabetes rats
    Chen, Xiao
    Famurewa, Ademola C.
    Tang, Jian
    Olatunde, Oladipupo Odunayo
    Olatunji, Opeyemi Joshua
    NUTRITIONAL NEUROSCIENCE, 2022, 25 (08) : 1774 - 1784
  • [10] Naringin ameliorates 5-fluorouracil elicited neurotoxicity by curtailing oxidative stress and iNOS/NF-κB/caspase-3 pathway
    Zhou, Peili
    Wang, Zhongfang
    Chen, Cheng
    Famurewa, Ademola C.
    Olatunji, Opeyemi Joshua
    OPEN CHEMISTRY, 2023, 21 (01):