Transcytosis of GCSF-Transferrin Across Rat Alveolar Epithelial Cell Monolayers

被引:0
|
作者
Adam Widera
Kwang-Jin J. Kim
Edward D. Crandall
Wei-Chiang Shen
机构
[1] University of Southern California,Department of Pharmaceutical Sciences, School of Pharmacy
[2] University of Southern California,Department of Medicine, Will Rogers Institute Pulmonary Research Center, Keck School of Medicine
来源
Pharmaceutical Research | 2003年 / 20卷
关键词
transferrin; alveolar epithelial cells; protein drug delivery; pulmonary drug delivery; BFA;
D O I
暂无
中图分类号
学科分类号
摘要
Purpose. The purpose of this study was to use primary cultured rat alveolar epithelial cell monolayers to examine the potential of using transferrin receptor (TfR)-mediated transcytosis for noninvasive systemic protein drug delivery via the pulmonary route.
引用
收藏
页码:1231 / 1238
页数:7
相关论文
共 50 条
  • [31] REGULATION OF TRANSPORT ACROSS PULMONARY ALVEOLAR EPITHELIAL-CELL MONOLAYERS
    GOODMAN, BE
    BROWN, SES
    CRANDALL, ED
    JOURNAL OF APPLIED PHYSIOLOGY, 1984, 57 (03) : 703 - 710
  • [32] Nanoparticles can injure and translocate across alveolar epithelial cell monolayers
    Yaghoobian, N
    DeMaio, L
    Liang, C
    Xie, J
    Hamm-Alvarez, S
    Peng, CA
    Borok, Z
    Crandall, ED
    Kim, KJ
    FASEB JOURNAL, 2006, 20 (05): : A1439 - A1439
  • [33] Mechanisms of liquid flux across pulmonary alveolar epithelial cell monolayers
    Filippatos G.S.
    Frank Hughes W.
    Qiao R.
    Iasha Sznajder J.
    Uhal B.D.
    In Vitro Cellular & Developmental Biology - Animal, 1997, 33 (3) : 195 - 200
  • [34] Mechanisms of Polystyrene Nanoparticle Translocation across Alveolar Epithelial Cell Monolayers
    Yacobi, N. R.
    Malmstadt, N.
    Fazlollahi, F.
    Marchelletta, R.
    Hamm-Alvarez, S. F.
    Borok, Z.
    Kim, K. J.
    Crandall, E. D.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179
  • [35] INFLUENCE OF LIPOPHILICITY ON BETA-BLOCKER PERMEATION ACROSS RAT ALVEOLAR EPITHELIAL-CELL MONOLAYERS
    SAHA, P
    KIM, KJ
    YAMAHARA, H
    CRANDALL, ED
    LEE, VHL
    JOURNAL OF CONTROLLED RELEASE, 1994, 32 (02) : 191 - 200
  • [36] Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers
    Kim, KJ
    Borok, Z
    Ehrhardt, C
    Willis, BC
    Lehr, CM
    Crandall, ED
    JOURNAL OF APPLIED PHYSIOLOGY, 2005, 98 (01) : 138 - 143
  • [37] Rapid and saturable net absorptive transport of immunoglobulin G (IgG) across rat alveolar epithelial cell monolayers
    Fandy, TE
    Lee, VHL
    Crandall, ED
    Kim, KJ
    MOLECULAR BIOLOGY OF THE CELL, 2000, 11 : 295A - 295A
  • [38] Enhancement of Insulin Transport Across Primary Rat Alveolar Epithelial Cell Monolayers by Endogenous Cellular Factor(s)
    Rana Bahhady
    Kwang-Jin Kim
    Zea Borok
    Edward D. Crandall
    Wei-Chiang Shen
    Pharmaceutical Research, 2007, 24 : 1713 - 1719
  • [39] Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s)
    Bahhady, Rana
    Kim, Kwang-Jin
    Borok, Zea
    Crandall, Edward D.
    Shen, Wei-Chiang
    PHARMACEUTICAL RESEARCH, 2007, 24 (09) : 1713 - 1719
  • [40] TNFα increases paracellular conductance in rat alveolar epithelial cell monolayers (RAECM)
    Firoozi, K
    Kim, KJ
    Balverde, Z
    Crandall, ED
    Borok, Z
    FASEB JOURNAL, 2005, 19 (05): : A1293 - A1293