Chloride extrusion enhancers as novel therapeutics for neurological diseases

被引：0
|
作者：
Martin Gagnon
Marc J Bergeron
Guillaume Lavertu
Annie Castonguay
Sasmita Tripathy
Robert P Bonin
Jimena Perez-Sanchez
Dominic Boudreau
Bin Wang
Lionel Dumas
Isabelle Valade
Karine Bachand
Mariève Jacob-Wagner
Christian Tardif
Irenej Kianicka
Paul Isenring
Giorgio Attardo
Jeffrey A M Coull
Yves De Koninck
机构：
[1] Institut Universitaire en Santé Mentale de Québec,Department of Psychiatry & Neuroscience
[2] Université Laval,undefined
[3] Chlorion Pharma,undefined
[4] Graduate Program in Biophotonics,undefined
[5] Université Laval,undefined
[6] Centre de Recherche du Centre Hospitalier Universitaire de Québec,undefined
来源：
Nature Medicine | 2013年 / 19卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Dysfunction of the potassium-chloride cotransporter KCC2 has been linked to many neurological diseases, including pain, anxiety and epilepsy. Now, Yves De Koninck and his colleagues report that they have developed a novel small-molecule compound that is orally bioavailable and can activate KCC2 and reduce chronic pain in rats.
引用
收藏
页码：1524 / 1528
页数：4
相关论文
共 50 条
  • [31] Therapeutics for neurological indications
    Dalziel, Chris
    Veryard, Claire
    IDRUGS, 2007, 10 (10) : 676 - 677
  • [32] NEUROLOGICAL BEARINGS OF THERAPEUTICS
    EMILE, J
    OUEST MEDICAL, 1974, 27 (10): : 979 - 980
  • [33] Recent neurological therapeutics
    Macbride, HJ
    Carmichael, EA
    LANCET, 1924, 2 : 958 - 959
  • [34] Novel therapeutic options to treat neurological diseases
    不详
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2013, 94 (04) : 423 - 423
  • [35] Apoptosis—New Opportunities for Novel Therapeutics for Heart Diseases
    Giora Z. Feuerstein
    Cardiovascular Drugs and Therapy, 2001, 15 : 547 - 551
  • [36] Apoptosis - New opportunities for novel therapeutics for heart diseases
    Feuerstein, GZ
    CARDIOVASCULAR DRUGS AND THERAPY, 2001, 15 (06) : 547 - 551
  • [37] PHARMACOPERONES AS NOVEL THERAPEUTICS FOR DIVERSE PROTEIN CONFORMATIONAL DISEASES
    Tao, Ya-Xiong
    Conn, P. Michael
    PHYSIOLOGICAL REVIEWS, 2018, 98 (02) : 697 - 725
  • [38] Novel Allosteric Destabilizers as Therapeutics for Genetic Diseases and Trauma
    Groppe, Jay Clemens
    Lu, Guorong
    Dawson, Alyssa
    Dawson, Trenton
    FASEB JOURNAL, 2016, 30
  • [39] MicroRNA-22: a Novel and Potent Biological Therapeutics in Neurological Disorders
    Seyed Hamidreza Rastegar-moghaddam
    Alireza Ebrahimzadeh-Bideskan
    Sara Shahba
    Amir Mohammad Malvandi
    Abbas Mohammadipour
    Molecular Neurobiology, 2022, 59 : 2694 - 2701
  • [40] MicroRNA-22: a Novel and Potent Biological Therapeutics in Neurological Disorders
    Rastegar-Moghaddam, Seyed Hamidreza
    Ebrahimzadeh-Bideskan, Alireza
    Shahba, Sara
    Malvandi, Amir Mohammad
    Mohammadipour, Abbas
    MOLECULAR NEUROBIOLOGY, 2022, 59 (05) : 2694 - 2701
12345