Chloride extrusion enhancers as novel therapeutics for neurological diseases

被引：0
|
作者：
Martin Gagnon
Marc J Bergeron
Guillaume Lavertu
Annie Castonguay
Sasmita Tripathy
Robert P Bonin
Jimena Perez-Sanchez
Dominic Boudreau
Bin Wang
Lionel Dumas
Isabelle Valade
Karine Bachand
Mariève Jacob-Wagner
Christian Tardif
Irenej Kianicka
Paul Isenring
Giorgio Attardo
Jeffrey A M Coull
Yves De Koninck
机构：
[1] Institut Universitaire en Santé Mentale de Québec,Department of Psychiatry & Neuroscience
[2] Université Laval,undefined
[3] Chlorion Pharma,undefined
[4] Graduate Program in Biophotonics,undefined
[5] Université Laval,undefined
[6] Centre de Recherche du Centre Hospitalier Universitaire de Québec,undefined
来源：
Nature Medicine | 2013年 / 19卷
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D O I：
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中图分类号：
学科分类号：
摘要：
Dysfunction of the potassium-chloride cotransporter KCC2 has been linked to many neurological diseases, including pain, anxiety and epilepsy. Now, Yves De Koninck and his colleagues report that they have developed a novel small-molecule compound that is orally bioavailable and can activate KCC2 and reduce chronic pain in rats.
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页码：1524 / 1528
页数：4
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