BRD4 and Cancer: going beyond transcriptional regulation

被引：0
|
作者：
Benedetta Donati
Eugenia Lorenzini
Alessia Ciarrocchi
机构：
[1] Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia,Laboratory of Translational Research
来源：
Molecular Cancer | / 17卷
关键词：
BRD4; BET inhibitors; Transcriptional regulation; DNA damage response; Telomere regulation; Unconventional function; Cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes expression regulation. Inhibition of BRD4 shortcuts the communication between SEs and target promoters with a subsequent cell-specific repression of oncogenes to which cancer cells are addicted and cell death. To date, this is the most credited mechanism of action of BET inhibitors, a class of small molecules targeting BET proteins which are currently in clinical trials in several cancer settings.
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