The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

被引:0
|
作者
Wataru Ise
Masako Kohyama
Barbara U Schraml
Tingting Zhang
Bjoern Schwer
Uttiya Basu
Frederick W Alt
Jun Tang
Eugene M Oltz
Theresa L Murphy
Kenneth M Murphy
机构
[1] Washington University School of Medicine,Department of Pathology and Immunology
[2] Howard Hughes Medical Institute,undefined
[3] The Children's Hospital,undefined
[4] the Immune Disease Institute and the Harvard Medical School,undefined
来源
Nature Immunology | 2011年 / 12卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
The transcription factor BATF is known to control switched antibody responses. Murphy and colleagues show that BATF functions at multiple hierarchical levels in follicular helper T cells and B cells to regulate these responses.
引用
收藏
页码:536 / 543
页数:7
相关论文
共 50 条
  • [21] Tumor-Associated CD19+CD39- B Regulatory Cells Deregulate Class-Switch Recombination to Suppress Antibody Responses
    Pati, Subhadip
    Mukherjee, Sumon
    Dutta, Saikat
    Guin, Aharna
    Roy, Dia
    Bose, Sayantan
    Paul, Silpita
    Saha, Sudipto
    Bhattacharyya, Sankar
    Datta, Pratyush
    Chakraborty, Jayati
    Sarkar, Diptendra K.
    Sa, Gaurisankar
    CANCER IMMUNOLOGY RESEARCH, 2023, 11 (03) : 364 - 380
  • [22] DIRECTED IG CLASS SWITCH RECOMBINATION IN ACTIVATED MURINE-B CELLS
    WINTER, E
    KRAWINKEL, U
    RADBRUCH, A
    EMBO JOURNAL, 1987, 6 (06): : 1663 - 1671
  • [23] The lymphoid follicles in primary cutaneous plasmacytosis may function as a tertiary lymphoid structure, playing a critical role in the differentiation of B cells and class-switch recombination
    Takishima, H.
    Kogame, T.
    Takase, K.
    Hata, A.
    Kabashima, K.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2023, 143 (05) : S16 - S16
  • [24] Ongoing immunoglobulin class switch DNA recombination in lupus B cells: Analysis of switch regulatory regions
    Liu, SQ
    Cerutti, A
    Casali, P
    Crow, MK
    AUTOIMMUNITY, 2004, 37 (6-7) : 431 - 443
  • [25] Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses
    Ruane, Darren
    Chorny, Alejo
    Lee, Haekyung
    Faith, Jeremiah
    Pandey, Gaurav
    Shan, Meimei
    Simchoni, Noa
    Rahman, Adeeb
    Garg, Aakash
    Weinstein, Erica G.
    Oropallo, Michael
    Gaylord, Michelle
    Ungaro, Ryan
    Cunningham-Rundles, Charlotte
    Alexandropoulos, Konstantina
    Mucida, Daniel
    Merad, Miriam
    Cerutti, Andrea
    Mehandru, Saurabh
    JOURNAL OF EXPERIMENTAL MEDICINE, 2016, 213 (01): : 53 - 73
  • [26] Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP-/- B cells
    Reina-San-Martin, Bernardo
    Chen, Junjie
    Nussenzweig, Andre
    Nussenzweig, Michel C.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (01) : 235 - 239
  • [27] DNA-PKcs Is Involved in Ig Class Switch Recombination in Human B Cells
    Bjorkman, Andrea
    Du, Likun
    Felgentreff, Kerstin
    Rosner, Cornelia
    Kamdar, Radhika Pankaj
    Kokaraki, Georgia
    Matsumoto, Yoshihisa
    Davies, E. Graham
    van der Burg, Mirjam
    Notarangelo, Luigi D.
    Hammarstrom, Lennart
    Pan-Hammarstrom, Qiang
    JOURNAL OF IMMUNOLOGY, 2015, 195 (12): : 5608 - 5615
  • [28] Predicting class switch recombination in B-cells from antibody repertoire data
    Servius, Lutecia
    Pigoli, Davide
    Ng, Joseph
    Fraternali, Franca
    BIOMETRICAL JOURNAL, 2024, 66 (04)
  • [29] Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination
    Svensson, Mattias N. D.
    Andersson, Karin M. E.
    Wasen, Caroline
    Erlandsson, Malin C.
    Nurkkala-Karlsson, Merja
    Jonsson, Ing-Marie
    Brisslert, Mikael
    Bemark, Mats
    Bokarewa, Maria I.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (48) : E6644 - E6653
  • [30] Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells
    Thuy Vy Nguyen
    Riou, Lydia
    Aoufouchi, Said
    Rosselli, Filippo
    JOURNAL OF EXPERIMENTAL MEDICINE, 2014, 211 (06): : 1011 - 1018