OCT4 and NANOG are the key genes in the system of pluripotency maintenance in mammalian cells

被引：0
|
作者：
S. P. Medvedev
A. I. Shevchenko
N. A. Mazurok
S. M. Zakian
机构：
[1] Russian Academy of Sciences,Institute of Cytology and Genetics
来源：
Russian Journal of Genetics | 2008年 / 44卷
关键词：
Embryonic Stem Cell; Human Embryonic Stem Cell; Inner Cell Mass; Oct4 Expression; Oct4 Gene;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Embryonic stem cells are able to give rise after differentiation to derivatives of three germinal layers (ectoderm, endoderm, and mesoderm) and to functional gametes. This property of cells is referred to as pluripotency. The pluripotent status of preimplantation embryo cells and embryonic stem cells is maintained by a complex system of molecular signaling pathways and transcription factors. The key regulators in this system are the transcription factors OCT4 and NANOG. The role and place of these factors in the pluripotency-maintaining system and their interaction with other factors are considered in the review. Data are presented on the structure, chromosomal location, expression, and regulation of the Oct4 and Nanog genes in mammals.
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页码：1377 / 1393
页数：16
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