Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

被引：0
|
作者：
Matan Sorek
Walaa Oweis
Malka Nissim-Rafinia
Moria Maman
Shahar Simon
Cynthia C. Hession
Xian Adiconis
Sean K. Simmons
Neville E. Sanjana
Xi Shi
Congyi Lu
Jen Q. Pan
Xiaohong Xu
Mahmoud A. Pouladi
Lisa M. Ellerby
Feng Zhang
Joshua Z. Levin
Eran Meshorer
机构：
[1] The Hebrew University of Jerusalem,Department of Genetics, The Alexander Silberman Institute of Life Sciences, Edmond J. Safra Campus
[2] The Hebrew University of Jerusalem,The Edmond and Lily Center for Brain Sciences, Edmond J. Safra Campus
[3] Broad Institute of MIT and Harvard,Stanley Center for Psychiatric Research
[4] Broad Institute of MIT and Harvard,Klarman Cell Observatory
[5] Broad Institute of MIT and Harvard,McGovern Institute for Brain Research
[6] Massachusetts Institute of Technology,New York Genome Center and Department of Biology
[7] New York University,Department of Neurology and Stroke Center, The First Affiliated Hospital
[8] Jinan University,Translational Laboratory in Genetic Medicine (TLGM), Agency for Science
[9] Technology and Research (A*STAR),Department of Physiology
[10] National University of Singapore,British Columbia Children’s Hospital Research Institute, Department of Medical Genetics
[11] University of British Columbia,Department of Biological Engineering
[12] Buck Institute for Research on Aging,Department of Brain and Cognitive Sciences
[13] Massachusetts Institute of Technology,undefined
[14] Massachusetts Institute of Technology,undefined
来源：
Genome Biology | / 22卷
关键词：
Transcriptional heterogeneity; Single cell; scRNA-seq; Neurological diseases; Neurodegenerative diseases; Huntington’s disease; Pluripotent stem cells; Stem cell model; Smart-seq2;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations
    Farra, N.
    Zhang, W-B
    Pasceri, P.
    Eubanks, J. H.
    Salter, M. W.
    Ellis, J.
    MOLECULAR PSYCHIATRY, 2012, 17 (12) : 1261 - 1271
  • [32] Human pluripotent stem cell-derived eosinophils reveal potent cytotoxicity against solid tumors
    Lai, Weifeng
    Xie, Huangfan
    Liu, Yuting
    Zheng, Feng
    Zhang, Yingfeng
    Lei, Qi
    Lv, Lejun
    Dong, Jiebin
    Song, Jian
    Gao, Xue
    Yin, Ming
    Wang, Chengyan
    Deng, Hongkui
    STEM CELL REPORTS, 2021, 16 (07): : 1697 - 1704
  • [33] Concise Review: Modeling Neurodegenerative Diseases with Human Pluripotent Stem Cell-Derived Microglia
    Haenseler, Walther
    Rajendran, Lawrence
    STEM CELLS, 2019, 37 (06) : 724 - 730
  • [34] Modeling human liver organ development and diseases with pluripotent stem cell-derived organoids
    Ouchi, Rie
    Koike, Hiroyuki
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2023, 11
  • [35] Mapping the Transcriptional Dynamics of Pluripotent Stem Cell-derived Endothelial Cell Differentiation by Single Cell RNA Sequencing
    McCracken, Ian R.
    Taylor, Richard S.
    De La Cuesta, Fernando
    Dobie, Ross
    Henderson, Beth E.
    Mountford, Joanne C.
    Caudrillier, Axelle
    Henderson, Neil C.
    Ponting, Chris P.
    Baker, Andrew H.
    CIRCULATION RESEARCH, 2019, 125
  • [36] Human pluripotent stem cell-derived cardiomyocytes mimic intercellular heterogeneity as pathomechanism in Hypertrophic Cardiomyopathy
    Montag, J.
    Weber, N.
    Kowalski, K.
    Mayer, A. K.
    Iorga, B.
    Brunkhorst, A.
    Zweigerdt, R.
    Kraft, T.
    ACTA PHYSIOLOGICA, 2022, 236 : 107 - 107
  • [37] Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias
    Dinesh Selvakumar
    Zoe E. Clayton
    Andrew Prowse
    Steve Dingwall
    Sul Ki Kim
    Leila Reyes
    Jacob George
    Haisam Shah
    Siqi Chen
    Halina H. L. Leung
    Robert D. Hume
    Laurentius Tjahjadi
    Sindhu Igoor
    Rhys J. P. Skelton
    Alfred Hing
    Hugh Paterson
    Sheryl L. Foster
    Lachlan Pearson
    Emma Wilkie
    Alan D. Marcus
    Prajith Jeyaprakash
    Zhixuan Wu
    Han Shen Chiu
    Cherica Felize J. Ongtengco
    Onkar Mulay
    Jeffrey R. McArthur
    Tony Barry
    Juntang Lu
    Vu Tran
    Richard Bennett
    Yasuhito Kotake
    Timothy Campbell
    Samual Turnbull
    Anunay Gupta
    Quan Nguyen
    Guiyan Ni
    Stuart M. Grieve
    Nathan J. Palpant
    Faraz Pathan
    Eddy Kizana
    Saurabh Kumar
    Peter P. Gray
    James J. H. Chong
    Nature Cardiovascular Research, 2024, 3 : 145 - 165
  • [38] Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cells
    Fernandes, Ian
    Funakoshi, Shunsuke
    Hamidzada, Homaira
    Epelman, Slava
    Keller, Gordon
    NATURE COMMUNICATIONS, 2023, 14 (01)
  • [39] Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias
    Selvakumar, Dinesh
    Clayton, Zoe E.
    Prowse, Andrew
    Dingwall, Steve
    Kim, Sul Ki
    Reyes, Leila
    George, Jacob
    Shah, Haisam
    Chen, Siqi
    Leung, Halina H. L.
    Hume, Robert D.
    Tjahjadi, Laurentius
    Igoor, Sindhu
    Skelton, Rhys J. P.
    Hing, Alfred
    Paterson, Hugh
    Foster, Sheryl L.
    Pearson, Lachlan
    Wilkie, Emma
    Marcus, Alan D.
    Jeyaprakash, Prajith
    Wu, Zhixuan
    Chiu, Han Shen
    Ongtengco, Cherica Felize J.
    Mulay, Onkar
    Mcarthur, Jeffrey R.
    Barry, Tony
    Lu, Juntang
    Tran, Vu
    Bennett, Richard
    Kotake, Yasuhito
    Campbell, Timothy
    Turnbull, Samual
    Gupta, Anunay
    Nguyen, Quan
    Ni, Guiyan
    Grieve, Stuart M.
    Palpant, Nathan J.
    Pathan, Faraz
    Kizana, Eddy
    Kumar, Saurabh
    Gray, Peter P.
    Chong, James J. H.
    NATURE CARDIOVASCULAR RESEARCH, 2024, 3 (02): : 145 - 165
  • [40] Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cells
    Ian Fernandes
    Shunsuke Funakoshi
    Homaira Hamidzada
    Slava Epelman
    Gordon Keller
    Nature Communications, 14
12345