Correction: Corrigendum: Light exposure before learning improves memory consolidation at night

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Li-Li Shan
Hao Guo
Ning-Ning Song
Zheng-Ping Jia
Xin-Tian Hu
Jing-Fei Huang
Yu-Qiang Ding
Gal Richter-Levin
Qi-Xin Zhou
Lin Xu
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Light is recently recognized as a modulator able to activate the hippocampus and modulate memory processing, but little is known about the molecular mechanisms. Here, we report that in mice, a short pulse of white light before learning dramatically improves consolidation of contextual fear memory during the night. The light exposure increases hippocampal active p21-activated kinase 1 (PAK1) and CA1 long-term potentiation (LTP). These light effects are abolished in PAK1 knockout and dominant-negative transgenic mice, but preserved by expression of constitutively active PAK1 in the hippocampus. Our results indicate that light can act as a switch of PAK1 activity that modulate CA1 LTP and thereby memory consolidation without affecting learning and short-term memory.
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