Serum brain-derived neurotrophic factor is associated with reduced appetite in healthy older adults

被引:0
|
作者
K. Stanek
J. Gunstad
T. Leahey
E. Glickman
T. Alexander
M. B. Spitznagel
J. Juvancic-Heltzel
L. Murray
机构
[1] Kent State University,Department of Psychology
[2] Center for Neuropsychological Studies,Department of Psychiatry, Summa Health System
[3] Kent State University,School of Exercise Leisure and Sport, The Exercise Science Laboratory
[4] Summa Health System,Department of Pathology
[5] Walsh University,Department of Physical Therapy
[6] Kent State University,undefined
来源
The Journal of Nutrition Health and Aging | 2008年 / 12卷
关键词
Brain-derived neurotrophic factor; appetite; body composition; elderly;
D O I
暂无
中图分类号
学科分类号
摘要
Objective: Loss of appetite and body mass are common in older adults and are associated with negative consequences. Research indicates that these processes likely involve increases in serum brain-derived neurotrophic factor (BDNF). Animal and human models demonstrate that BDNF may serve a regulatory function in food intake, but no study has addressed the possibility that BDNF may be involved in appetite reduction and loss of body mass in older adults.Design and Participants: 34 older adults without significant neurological or psychiatric history underwent fasting blood draw and measurement of body composition. Appetite and eating behavior were assessed by questionnaire and related to serum BDNF levels.Results: Partial correlations showed serum BDNF levels were inversely related to appetite (r = −.38, p = .02). No significant correlations emerged between serum BDNF and age, diet, or body composition.Conclusions: The current study extends past work and shows that BDNF is associated with appetite in healthy older adults. Further work is needed to clarify mechanisms for these findings, particularly prospective studies.
引用
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页码:183 / 185
页数:2
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