Functioning of P-Glycoprotein during Pregnancy in Rabbits

被引：0
|
作者：
N. M. Popova
A. V. Shchulkin
I. V. Chernykh
P. Yu. Mylnikov
E. N. Yakusheva
机构：
[1] Ryazan State Medical University,
[2] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2023年 / 174卷
关键词：
P-glycoprotein (Pgp, ABCB1-protein); protein content; protein activity; fexofenadine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The level P-glycoprotein (Pgp) in organs of pregnant rabbits and its content and activity in the placental barrier at different stages of pregnancy were studied. An increase in Pgp content in the jejunum on days 7, 14, 21, and 28 of pregnancy in comparison with this parameter non-pregnant females was revealed by ELISA; in the liver, Pgp content was higher on day 7 and tended to increase on day 14; in the kidney and cerebral cortex, Pgp content was higher on day 28 of pregnancy in parallel with an increase in serum progesterone concentration. We also observed a decrease in Pgp content in the placenta on days 21 and 28 of pregnancy in comparison with day 14 and a decrease in Pgp activity in the placental barrier, which was confirmed by enhanced penetration of fexofenadine (Pgp substrate) through the barrier.
引用
收藏
页码：431 / 434
页数：3
相关论文
共 50 条
  • [1] Functioning of P-Glycoprotein during Pregnancy in Rabbits
    Popova, N. M.
    Shchulkin, A. V.
    Chernykh, I. V.
    Mylnikov, P. Yu.
    Yakusheva, E. N.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2023, 174 (04) : 431 - 434
  • [2] P-glycoprotein expression of the human placenta during pregnancy
    Gil, S
    Saura, R
    Forestier, F
    Farinotti, R
    PLACENTA, 2005, 26 (2-3) : 268 - 270
  • [3] P-glycoprotein expression and distribution in the rat placenta during pregnancy
    Novotna, M
    Libra, A
    Kopecky, M
    Pavek, P
    Fendrich, Z
    Semecky, V
    Staud, F
    REPRODUCTIVE TOXICOLOGY, 2004, 18 (06) : 785 - 792
  • [4] The Role of Testosterone in the Regulation of P-Glycoprotein Functioning
    Shchulkin, A. V.
    Yakusheva, E. N.
    Chernykh, I. V.
    Nikiforov, A. A.
    BIOLOGY BULLETIN, 2017, 44 (05) : 524 - 530
  • [5] The role of testosterone in the regulation of P-glycoprotein functioning
    A. V. Shchulkin
    E. N. Yakusheva
    I. V. Chernykh
    A. A. Nikiforov
    Biology Bulletin, 2017, 44 : 524 - 530
  • [6] Influence of Gold Glyconanoparticles on the Functioning of P-Glycoprotein In Vitro
    Kopanitsa, M. A.
    Chernykh, I. V.
    Shchulkin, A. V.
    Mylnikov, P. Yu.
    Ershov, A. Yu.
    Lagoda, I. V.
    Martynenkov, A. A.
    Yakusheva, E. N.
    NANOBIOTECHNOLOGY REPORTS, 2024, 19 (01) : 165 - 171
  • [7] Effect of Nitric Oxide on the Functioning of the P-Glycoprotein Transporter
    Abalenikhina, Yu, V
    Sudakova, E. A.
    Slepnev, A. A.
    Shchul'kin, A., V
    Yakusheva, E. N.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2022, 173 (01) : 28 - 32
  • [8] Effect of Nitric Oxide on the Functioning of the P-Glycoprotein Transporter
    Yu. V. Abalenikhina
    E. A. Sudakova
    A. A. Slepnev
    A. V. Shchul’kin
    E. N. Yakusheva
    Bulletin of Experimental Biology and Medicine, 2022, 173 : 28 - 32
  • [9] Role of P-glycoprotein in blood-aqueous barrier in rabbits
    Kajikawa, T
    Mishima, HK
    Murakami, T
    Takano, M
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1999, 40 (04) : S501 - S501
  • [10] Role of P-glycoprotein in ocular clearance of rhodamine 123 in rabbits
    Kajikawa, T
    Mishima, HK
    Murakami, T
    Takano, M
    PHARMACEUTICAL RESEARCH, 2000, 17 (04) : 479 - 481
12345