Anti-inflammatory activity of a polypeptide from the Heteractis crispa sea anemone
被引:0
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作者:
O. V. Sintsova
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机构:Far Eastern Branch,Elyakov Pacific Institute of Bioorganic Chemistry
O. V. Sintsova
M. M. Monastyrnaya
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机构:Far Eastern Branch,Elyakov Pacific Institute of Bioorganic Chemistry
M. M. Monastyrnaya
E. A. Pislyagin
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机构:Far Eastern Branch,Elyakov Pacific Institute of Bioorganic Chemistry
E. A. Pislyagin
E. S. Menchinskaya
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机构:Far Eastern Branch,Elyakov Pacific Institute of Bioorganic Chemistry
E. S. Menchinskaya
E. V. Leychenko
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机构:Far Eastern Branch,Elyakov Pacific Institute of Bioorganic Chemistry
E. V. Leychenko
D. L. Aminin
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机构:Far Eastern Branch,Elyakov Pacific Institute of Bioorganic Chemistry
D. L. Aminin
E. P. Kozlovskaya
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机构:Far Eastern Branch,Elyakov Pacific Institute of Bioorganic Chemistry
E. P. Kozlovskaya
机构:
[1] Far Eastern Branch,Elyakov Pacific Institute of Bioorganic Chemistry
[2] Russian Academy of Sciences,undefined
来源:
Russian Journal of Bioorganic Chemistry
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2015年
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41卷
关键词:
sea anemones;
the Kunitz-type protease inhibitors;
antihistamine activity;
anti-inflammatory activity;
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学科分类号:
摘要:
The anti-inflammatory activity of the HCGS 1.20 recombinant polypeptide (a Kunitz-type serine protease inhibitor from the Heteractis crispa sea anemone) was investigated. The polypeptide was shown to inhibit the histamine-induced increase in the concentration of calcium ions and the lipopolysaccharidestimulated increase in the concentration of nitric oxide (II) in macrophages. A possible mechanism of this anti-inflammatory activity of the polypeptide was discussed.
机构:Hainan Medical University,Engineering Research Center of Tropical Medicine Innovation and Transformation, Ministry of Education, International Joint Research Center of Human
Qiqi Guo
Jinxing Fu
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机构:Hainan Medical University,Engineering Research Center of Tropical Medicine Innovation and Transformation, Ministry of Education, International Joint Research Center of Human
Jinxing Fu
Lin Yuan
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机构:Hainan Medical University,Engineering Research Center of Tropical Medicine Innovation and Transformation, Ministry of Education, International Joint Research Center of Human
Lin Yuan
Yanling Liao
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机构:Hainan Medical University,Engineering Research Center of Tropical Medicine Innovation and Transformation, Ministry of Education, International Joint Research Center of Human
Yanling Liao
Ming Li
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机构:Hainan Medical University,Engineering Research Center of Tropical Medicine Innovation and Transformation, Ministry of Education, International Joint Research Center of Human
Ming Li
Xinzhong Li
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机构:Hainan Medical University,Engineering Research Center of Tropical Medicine Innovation and Transformation, Ministry of Education, International Joint Research Center of Human
Xinzhong Li
Bo Yi
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机构:Hainan Medical University,Engineering Research Center of Tropical Medicine Innovation and Transformation, Ministry of Education, International Joint Research Center of Human
Bo Yi
Junqing Zhang
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机构:Hainan Medical University,Engineering Research Center of Tropical Medicine Innovation and Transformation, Ministry of Education, International Joint Research Center of Human
Junqing Zhang
Bingmiao Gao
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机构:Hainan Medical University,Engineering Research Center of Tropical Medicine Innovation and Transformation, Ministry of Education, International Joint Research Center of Human