Anti-inflammatory activity of a polypeptide from the Heteractis crispa sea anemone

被引：0
|
作者：
O. V. Sintsova
M. M. Monastyrnaya
E. A. Pislyagin
E. S. Menchinskaya
E. V. Leychenko
D. L. Aminin
E. P. Kozlovskaya
机构：
[1] Far Eastern Branch,Elyakov Pacific Institute of Bioorganic Chemistry
[2] Russian Academy of Sciences,undefined
来源：
Russian Journal of Bioorganic Chemistry | 2015年 / 41卷
关键词：
sea anemones; the Kunitz-type protease inhibitors; antihistamine activity; anti-inflammatory activity;
D O I：
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中图分类号：
学科分类号：
摘要：
The anti-inflammatory activity of the HCGS 1.20 recombinant polypeptide (a Kunitz-type serine protease inhibitor from the Heteractis crispa sea anemone) was investigated. The polypeptide was shown to inhibit the histamine-induced increase in the concentration of calcium ions and the lipopolysaccharidestimulated increase in the concentration of nitric oxide (II) in macrophages. A possible mechanism of this anti-inflammatory activity of the polypeptide was discussed.
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页码：590 / 596
页数：6
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