The α2B adrenergic receptor deletion/insertion polymorphism in morbid obesity

被引：0

作者：

Gerasimos P. Sykiotis

Eftihia Polyzogopoulou

Neoklis A. Georgopoulos

Georgia Trakada

Kostas Spyropoulos

Fotios Kalfarentzos

Athanasios G. Papavassiliou

Apostolos G. Vagenakis

Christodoulos S. Flordellis

机构：

[1] Dept. of Pharmacology,

[2] School of Medicine,undefined

[3] University of Patras,undefined

[4] 26110 Patras,undefined

[5] Greece. flordell@med.upatras.gr,undefined

[6] Dept. of Internal Medicine (EP),undefined

[7] Divisions of Endocrinology,undefined

[8] (NAG,undefined

[9] AGV) & Pulmonology (GT,undefined

[10] KS),undefined

[11] Patras University Hospital,undefined

[12] Patras,undefined

[13] Greece,undefined

[14] Nutrition Support & Morbid Obesity Clinic,undefined

[15] Dept. of Surgery,undefined

[16] Patras University Hospital,undefined

[17] Patras,undefined

[18] Greece,undefined

[19] Dept. of Biochemistry,undefined

[20] Medical School,undefined

[21] University of Patras,undefined

[22] Patras,undefined

[23] Greece,undefined

[24] Current address: N. A. Georgopoulos,undefined

[25] Dept. of Obstetrics & Gynecology,undefined

[26] Division of Reproductive Endocrinology,undefined

[27] Patras University Hospital,undefined

[28] Patras,undefined

[29] Greece,undefined

来源：

Clinical Autonomic Research | 2003年 / 13卷

关键词：

Key words α2B adrenergic receptor polymorphism; morbid obesity; resting energy expenditure; metabolic syndrome;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The sympathetic nervous system participates in the regulation of the basal metabolic rate (BMR) and in the manifestation of the obesity-related metabolic syndrome. A deletion/insertion germline polymorphism of the α2B adrenergic receptor that is associated with reduced agonist-promoted desensitization has been linked to low BMR in obese subjects and to a predisposition to gain weight. This study investigated an association of the α2B polymorphism with the BMR and metabolic syndrome-related parameters of morbidly obese patients. Genotype frequencies were similar in patients and in a control group. The patients' BMR, adjusted for fat-free mass, fat mass, sex and age, did not differ between α2B genotypes. The polymorphism was also not associated with the patients' BMI, systolic and diastolic blood pressure, resting heart rate, total and HDL cholesterol, triglycerides, fasting glucose and uric acid levels. These findings do not support a major functional significance of the α2B adrenergic receptor polymorphism in the present sample of morbidly obese subjects.

引用

页码：203 / 207

页数：4

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