Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma

被引：0

作者：

Michael E Feigin

Tyler Garvin

Peter Bailey

Nicola Waddell

David K Chang

David R Kelley

Shimin Shuai

Steven Gallinger

John D McPherson

Sean M Grimmond

Ekta Khurana

Lincoln D Stein

Andrew V Biankin

Michael C Schatz

David A Tuveson

机构：

[1] Cold Spring Harbor Laboratory,Department of Surgery

[2] Lustgarten Foundation Pancreatic Cancer Research Laboratory,Department of Stem Cell and Regenerative Biology

[3] Watson School of Biological Sciences,Department of Molecular Genetics

[4] Cold Spring Harbor Laboratory,Division of General Surgery

[5] Wolfson Wohl Cancer Research Centre,Department of Physiology and Biophysics

[6] Institute of Cancer Sciences,Department of Computer Science

[7] University of Glasgow,Department of Biology

[8] Glasgow,undefined

[9] QIMR Berghofer Medical Research Institute,undefined

[10] Queensland Centre for Medical Genomics,undefined

[11] Institute for Molecular Bioscience,undefined

[12] The University of Queensland,undefined

[13] The Kinghorn Cancer Centre,undefined

[14] Cancer Research Program,undefined

[15] Garvan Institute of Medical Research,undefined

[16] Darlinghurst,undefined

[17] Bankstown Hospital,undefined

[18] Bankstown,undefined

[19] South Western Sydney Clinical School,undefined

[20] Faculty of Medicine,undefined

[21] University of New South Wales,undefined

[22] Harvard University,undefined

[23] University of Toronto,undefined

[24] Lunenfeld-Tanenbaum Research Institute,undefined

[25] Mount Sinai Hospital,undefined

[26] Toronto General Hospital,undefined

[27] Genome Technologies Program,undefined

[28] Ontario Institute for Cancer Research,undefined

[29] Sandra and Edward Meyer Cancer Center,undefined

[30] Institute for Computational Biomedicine,undefined

[31] Weill Medical College of Cornell University,undefined

[32] Informatics and Biocomputing,undefined

[33] Ontario Institute for Cancer Research,undefined

[34] Johns Hopkins University,undefined

[35] Johns Hopkins University,undefined

[36] Rubenstein Center for Pancreatic Cancer Research,undefined

[37] Memorial Sloan Kettering Cancer Center,undefined

[38] West of Scotland Pancreatic Unit,undefined

[39] Glasgow Royal Infirmary,undefined

[40] Present addresses: University of Melbourne Centre for Cancer Research,undefined

[41] University of Melbourne,undefined

[42] Melbourne,undefined

[43] Victoria,undefined

[44] Australia (S.M.G.) and Department of Biochemistry and Molecular Medicine,undefined

[45] UC Davis Comprehensive Cancer Center,undefined

[46] UC Davis School of Medicine,undefined

[47] University of California Davis,undefined

[48] Sacramento,undefined

[49] California,undefined

[50] USA (J.D.M.).,undefined

来源：

Nature Genetics | 2017年 / 49卷

关键词：

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学科分类号：

摘要：

Michael Schatz, David Tuveson and colleagues analyze somatic noncoding alterations in 308 pancreatic ductal adenocarcinomas. They find recurrent noncoding regulatory mutations that correlate with differential expression of proximal genes and find that the strongest regulatory elements are more frequently mutated, suggesting a selective advantage for mutations in these regions.

引用

页码：825 / 833

页数：8

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