The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling

被引：0
|
作者：
Jin Jin
Yichuan Xiao
Jae-Hoon Chang
Jiayi Yu
Hongbo Hu
Robyn Starr
George C Brittain
Mikyoung Chang
Xuhong Cheng
Shao-Cong Sun
机构：
[1] The University of Texas MD Anderson Cancer Center,Department of Immunology
[2] St. Vincent's Institute,undefined
[3] The University of Texas Graduate School of Biomedical Sciences at Houston,undefined
来源：
Nature Immunology | 2012年 / 13卷
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摘要：
How isotype-specific immunoglobulin production is regulated is largely unknown. Sun and colleagues show that the kinase TBK1 acts as a negative regulator of IgA class switching by attenuating NIK-mediated NF-κB signaling.
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页码：1101 / 1109
页数：8
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