The genetics of Parkinson's disease.

被引：16
|
作者：
Lim K.L. [1 ]
Dawson V.L. [1 ]
Dawson T.M. [1 ]
机构：
[1] Department of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Carnegie 214, 600 North Wolfe Street, Baltimore, 21287, MD
来源：
Current Neurology and Neuroscience Reports | 2002年 / 2卷 / 5期
关键词：
Parkin; Lewy Body; Progressive Supranuclear Palsy; Parkin Gene; Parkin Mutation;
D O I：
10.1007/s11910-002-0071-9
中图分类号：
学科分类号：
摘要：
The recent identification of several genes and gene loci linked to familial forms of Parkinson's disease (PD) has contributed significantly to our understanding of the genetic contribution in PD. Although the etiology of sporadic PD remains unknown, it is currently assumed that genetic susceptibilities may be involved. The advent of genome-wide scanning techniques has now made it possible to conduct complete genome screens for linkage in PD in multigenerational parkinsonian kindreds. Such studies undoubtedly will be instrumental in establishing the susceptibility genes involved in idiopathic PD. This article reviews the recent advances in the genetics of PD.
引用
收藏
页码：439 / 446
页数：7
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