Chromosome variability of human multipotent mesenchymal stromal cells

被引：0
|
作者：
N. P. Bochkov
E. S. Voronina
N. V. Kosyakova
T. Liehr
A. A. Rzhaninova
L. D. Katosova
V. I. Platonova
D. V. Gol’dshtein
机构：
[1] I. M. Setchenov Moscow Medical Academy,Medical Genetic Research Center
[2] Russian Academy of Medical Sciences,Institute of Human Genetics and Anthropology
[3] ReMeTeks Company,undefined
[4] Friedrich Schiller University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2007年 / 143卷
关键词：
multipotent mesenchymal stromal cells; karyotyping; aneuploidy; chromosome aberrations;
D O I：
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学科分类号：
摘要：
We elaborated a method of preparing cytogenetic preparations of cultured multipotent mesenchymal stromal cells from the adipose tissue. It was found that karyotypic changes (monosomy, translocations) appear in some samples during culturing. Clones with changed karyotype were detected in 11–14-passage cultures from 2 of 7 individuals. The percent of aberrant cells in cultures from different individuals varied from 1.5 to 5.95 per 100 cells, which attested to karyotype instability. These data substantiate the need for cytogenetic control of cells before their transplantation into donor organism and further investigation of chromosome variability in stem cells.
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页码：122 / 126
页数：4
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