The tylosin-biosynthetic genes of Streptomyces fradiae

被引：5
|
作者：
Eric Cundliffe
Neil Bate
Andrew Butler
Steven Fish
Atul Gandecha
Louise Merson-Davies
机构：
[1] University of Leicester,Department of Biochemistry
来源：
Antonie van Leeuwenhoek | 2001年 / 79卷
关键词：
deoxyhexose; γ-butyrolactone; macrolide; polyketide editing; thioesterase; tylosin;
D O I：
暂无
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学科分类号：
摘要：
The tylosin-biosynthetic (tyl) gene cluster occupies about 1% of the genome of Streptomyces fradiae and includes at least 43 open reading frames. In addition to structural genes required for tylosin production, the tylcluster contains three resistance determinants and several regulatory genes. Tylosin production is evidently controlled by pathway-specific and pleiotropic regulators with the likely involvement of γ-butyrolactone signalling factors. Accumulation of the polyketide aglycone is controlled by glycosylated macrolides and optimal performance of the complex polyketide synthase enzyme requires the activity of an editing thioesterase.
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页码：229 / 234
页数：5
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