Estimation of transmembrane potential of thymic lymphocytes during dexamethasone-induced apoptosis

被引：0
|
作者：
A. S. Dukhanin
D. V. Patrashev
机构：
[1] Russian State Medical University,
来源：
Bulletin of Experimental Biology and Medicine | 1999年 / 127卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The use of potential-sensitive fluorescent probes allowed us to estimate transmembrane potentials of the plasma (Δφp) and mitochondrial (Δφm) membranes of rat thymocytes, which were −58±3 mV and −169±7 mV, respectively. Dexamethasone-induced apoptosis led to a significant decrease in Δφp (by 55%) and Δφm (by 17%). This effects of dexamethasone was dose- and time-dependent. Changes in Δφm were greater and preceded those in Δφp.
引用
收藏
页码：106 / 109
页数：3
相关论文
共 50 条
  • [1] Estimation of transmembrane potential of thymic lymphocytes during dexamethasone-induced apoptosis
    Dukhanin, AS
    Patrashev, DV
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1999, 127 (01) : 106 - 109
  • [2] Alteration of phospholipase D activities during dexamethasone-induced thymic atrophy
    Lee, Y
    Kim, S
    Rohb, TY
    Hong, ST
    Lee, SJ
    Choi, MU
    FASEB JOURNAL, 2002, 16 (04): : A160 - A160
  • [3] ANALYSIS OF SUSCEPTIBILITY OF MATURE HUMAN T-LYMPHOCYTES TO DEXAMETHASONE-INDUCED APOPTOSIS
    Tuosto, L
    Cundari, E
    Gilardini Montani, MS
    Piccolella, E
    EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (05) : 1061 - 1065
  • [4] Effect of the triterpenoid miliacin on the sensitivity of lymphocytes in the thymus to dexamethasone-induced and spleen apoptosis
    Panfilova, TV
    Shtil', AA
    Polosukhina, ER
    Baryshnikov, AY
    Frolov, BA
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2003, 136 (04) : 336 - 339
  • [5] Proteasome activities decrease during dexamethasone-induced apoptosis of thymocytes
    Beyette, J
    Mason, GGF
    Murray, RZ
    Cohen, GM
    Rivett, AJ
    BIOCHEMICAL JOURNAL, 1998, 332 : 315 - 320
  • [6] Effect of the Triterpenoid Miliacin on the Sensitivity of Lymphocytes in the Thymus and Spleen to Dexamethasone-Induced Apoptosis
    T. V. Panfilova
    A. A. Shtil'
    E. R. Polosukhina
    A. Yu. Baryshnikov
    B. A. Frolov
    Bulletin of Experimental Biology and Medicine, 2003, 136 : 336 - 339
  • [7] Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis
    Lépine, S
    Lakatos, B
    Maziere, P
    Courageot, NP
    Sulpice, JC
    Giraud, F
    CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS, 2002, 973 : 190 - 193
  • [8] Tactivin in the regulation of dexamethasone-induced apoptosis in thymocytes
    Arion, V. Ya.
    Mel'nikova, V. I.
    Afanas'eva, M. A.
    Moskvina, S. N.
    Zakharova, L. A.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2007, 144 (03) : 479 - 481
  • [9] Intracellular alkalinization in dexamethasone-induced thymocyte apoptosis
    H-Y. Lei
    M-J. Tang
    N. Tsao
    Apoptosis, 1997, 2 : 304 - 312
  • [10] Tactivin in the regulation of dexamethasone-induced apoptosis in thymocytes
    V. Ya. Arion
    V. I. Mel’nikova
    M. A. Afanas’eva
    S. N. Moskvina
    L. A. Zakharova
    Bulletin of Experimental Biology and Medicine, 2007, 144 : 479 - 481
12345