Effect of the triterpenoid miliacin on the sensitivity of lymphocytes in the thymus to dexamethasone-induced and spleen apoptosis

被引：9
|
作者：
Panfilova, TV
Shtil', AA [1 ]
Polosukhina, ER
Baryshnikov, AY
Frolov, BA
机构：
[1] Orenburg State Med Acad, Orenburg, Russia
[2] NN Blokhin Russian Res Ctr Oncol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 136卷 / 04期
关键词：
lymphocytes; dexamethasone; apoptosis;
D O I：
10.1023/B:BEBM.0000010945.81238.b6
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of plant triterpenoid miliacin on dexamethasone-induced apoptosis in thymocytes and splenocytes. Miliacin produced a protective effect on splenocytes by decreasing the degree of DNA fragmentation due to blockade of the cascade cell death distally to the intramembrane phosphatidylserine translocation.
引用
收藏
页码：336 / 339
页数：4
相关论文
共 50 条
  • [1] Effect of the Triterpenoid Miliacin on the Sensitivity of Lymphocytes in the Thymus and Spleen to Dexamethasone-Induced Apoptosis
    T. V. Panfilova
    A. A. Shtil'
    E. R. Polosukhina
    A. Yu. Baryshnikov
    B. A. Frolov
    [J]. Bulletin of Experimental Biology and Medicine, 2003, 136 : 336 - 339
  • [2] Estimation of transmembrane potential of thymic lymphocytes during dexamethasone-induced apoptosis
    Dukhanin, AS
    Patrashev, DV
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1999, 127 (01) : 106 - 109
  • [3] Estimation of transmembrane potential of thymic lymphocytes during dexamethasone-induced apoptosis
    A. S. Dukhanin
    D. V. Patrashev
    [J]. Bulletin of Experimental Biology and Medicine, 1999, 127 : 106 - 109
  • [4] ANALYSIS OF SUSCEPTIBILITY OF MATURE HUMAN T-LYMPHOCYTES TO DEXAMETHASONE-INDUCED APOPTOSIS
    Tuosto, L
    Cundari, E
    Gilardini Montani, MS
    Piccolella, E
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (05) : 1061 - 1065
  • [5] SIMULTANEOUS EVALUATION OF DEXAMETHASONE-INDUCED APOPTOSIS AND MICRONUCLEI IN RAT PRIMARY SPLEEN-CELL CULTURES
    KRISHNA, G
    URDA, G
    TEFERA, W
    LALWANI, ND
    THEISS, J
    [J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1995, 332 (1-2) : 1 - 8
  • [6] Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis
    Lépine, S
    Lakatos, B
    Maziere, P
    Courageot, NP
    Sulpice, JC
    Giraud, F
    [J]. CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS, 2002, 973 : 190 - 193
  • [7] Intracellular alkalinization in dexamethasone-induced thymocyte apoptosis
    H-Y. Lei
    M-J. Tang
    N. Tsao
    [J]. Apoptosis, 1997, 2 : 304 - 312
  • [8] Tactivin in the regulation of dexamethasone-induced apoptosis in thymocytes
    Arion, V. Ya.
    Mel'nikova, V. I.
    Afanas'eva, M. A.
    Moskvina, S. N.
    Zakharova, L. A.
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2007, 144 (03) : 479 - 481
  • [9] Effect of bisphosphonates on viability, proliferation, and dexamethasone-induced apoptosis of articular chondrocytes
    Van Offel, JF
    Schuerwegh, AJ
    Bridts, CH
    Stevens, WJ
    De Clerck, LS
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2002, 61 (10) : 925 - 928
  • [10] Tactivin in the regulation of dexamethasone-induced apoptosis in thymocytes
    V. Ya. Arion
    V. I. Mel’nikova
    M. A. Afanas’eva
    S. N. Moskvina
    L. A. Zakharova
    [J]. Bulletin of Experimental Biology and Medicine, 2007, 144 : 479 - 481
12345