Cucurbit[8]uril-based supramolecular theranostics

被引：1

作者：

Wu, Dan ^{[1
,3
]}

Wang, Jianfeng ^{[2
]}

Du, Xianlong ^{[4
]}

Cao, Yibin ^{[3
]}

Ping, Kunmin ^{[3
]}

Liu, Dahai ^{[1
]}

机构：

[1] Jilin Univ, China Japan Union Hosp, Dept Vasc Surg, Changchun 130033, Peoples R China

[2] Jilin Univ, China Japan Union Hosp, Dept Radiotherapy, Changchun 130033, Peoples R China

[3] Zhejiang Univ Technol, Coll Mat Sci & Engn, Hangzhou 310014, Peoples R China

[4] Jilin Univ, Bethune Coll Clin Med 1, Changchun 130012, Peoples R China

来源：

JOURNAL OF NANOBIOTECHNOLOGY | 2024年 / 22卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Cucurbit[8]uril; Host-guest reactions; Self-assembly; Supramolecular nanomedicine; Supramolecular theranostics; GUEST MOLECULAR RECOGNITION; DRUG-DELIVERY; HOST-GUEST; INDOLEAMINE 2,3-DIOXYGENASE; PHOTODYNAMIC THERAPY; RNA-INTERFERENCE; CUCURBITURIL HOMOLOGS; CHARGE-TRANSFER; AMINO-ACIDS; IN-VITRO;

D O I：

10.1186/s12951-024-02349-z

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Different from most of the conventional platforms with dissatisfactory theranostic capabilities, supramolecular nanotheranostic systems have unparalleled advantages via the artful combination of supramolecular chemistry and nanotechnology. Benefiting from the tunable stimuli-responsiveness and compatible hierarchical organization, host-guest interactions have developed into the most popular mainstay for constructing supramolecular nanoplatforms. Characterized by the strong and diverse complexation property, cucurbit[8]uril (CB[8]) shows great potential as important building blocks for supramolecular theranostic systems. In this review, we summarize the recent progress of CB[8]-based supramolecular theranostics regarding the design, manufacture and theranostic mechanism. Meanwhile, the current limitations and corresponding reasonable solutions as well as the potential future development are also discussed.

引用

页数：27

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