Synthesis of 2-alkyl(aralkyl)sulfanyl-6-methylpyrimidin-4(3H)-ones and 4-alkyl(aralkyl)oxy-2-alkyl(aralkyl)sulfanyl-6-methylpyrimidines

被引：0

作者：

A. I. Rakhimov

E. S. Titova

机构：

[1] Volgograd State Technical University,

来源：

Russian Journal of Organic Chemistry | 2007年 / 43卷

关键词：

Colorless Crystal; Nucleophilic Substitution; Benzyl Chloride; Benzyl Bromide; Allyl Bromide;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

2-Alkyl(aralkyl)sulfanyl-6-methylpyrimidin-4(3H)-ones and 4-alkyl(aralkyl)oxy-2-alkyl(aralkyl)-sulfanyl-6-methylpyrimidines having similar or different substituents on the sulfur and oxygen atoms were synthesized by alkylation of sodium salts derived from 6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-one and 2-alkyl(aralkyl)sulfanyl-6-methylpyrimidin-4(3H)-ones with alkyl (propyl, ethyl, allyl) and aralkyl [benzyl, m-phenoxybenzyl, p-(1-adamantylbenzyl)] halides. The effects of the alkyl (aralkyl) halide nature and solvent polarity on the rate of nucleophilic substitution and product yield were studied.

引用

页码：96 / 102

页数：6

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