Synthesis of 2-alkyl(aralkyl)sulfanyl-6-methylpyrimidin-4(3H)-ones and 4-alkyl(aralkyl)oxy-2-alkyl(aralkyl)sulfanyl-6-methylpyrimidines

被引：0

作者：

Rakhimov, A. I. ^{[1
]}

Titova, E. S. ^{[1
]}

机构：

[1] Volgograd State Tech Univ, Volgograd 400131, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 43卷 / 01期

关键词：

D O I：

10.1134/S1070428007010125

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Alkyl(aralkyl)sulfanyl-6-methylpyrimidin-4(3H)-ones and 4-alkyl(aralkyl)oxy-2-alkyl(aralkyl)-sulfanyl-6-methylpyrimidines having similar or different substituents on the sulfur and oxygen atoms were synthesized by alkylation of sodium salts derived from 6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-one and 2-alkyl(aralkyl)sulfanyl-6-methylpyrimidin-4(3H)-ones with alkyl (propyl, ethyl, allyl) and aralkyl [benzyl, m-phenoxybenzyl, p-(1-adamantylbenzyl)] halides. The effects of the alkyl (aralkyl) halide nature and solvent polarity on the rate of nucleophilic substitution and product yield were studied.

引用

页码：96 / 102

页数：7

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