Wnt/β-catenin signalling in prostate cancer

被引：0
|
作者：
Robert M. Kypta
Jonathan Waxman
机构：
[1] Cell biology and Stem Cells Unit,Department of Surgery and Cancer
[2] Center for Cooperative Research in Biosciences,undefined
[3] CIC bioGUNE,undefined
[4] Imperial College London,undefined
来源：
Nature Reviews Urology | 2012年 / 9卷
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D O I：
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学科分类号：
摘要：
Dysregulation of Wnt signalling, a hallmark of which is the stabilization of the transcriptional co-activator β catenin, can lead to several types of cancer, including prostate cancer. Activation of the Wnt/β catenin pathway has effects on prostate cell proliferation, differentiation and the epithelial–mesenchymal transition. In this Review, the authors discuss how the pathway is activated and consider the possible therapeutic application of drugs that target Wnt/β catenin signalling.
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页码：418 / 428
页数：10
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