4-Hydroxy-2-quinolones 148. Synthesis and antitubercular activity of 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid N-R-amides

被引：0
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作者：
I. V. Ukrainets
A. A. Tkach
L. A. Grinevich
机构：
[1] National University of Pharmacy,
来源：
Chemistry of Heterocyclic Compounds | 2008年 / 44卷
关键词：
hetarylamides; 4-hydroxy-2-oxoquinoline-3-carboxylic acids; amidation; antitubercular activity; X-ray structural analysis;
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摘要：
An improved method for the preparation of ethyl 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate has been proposed and a series of hetarylamides has been synthesized from it. A comparative analysis has been carried out of the antitubercular activities of the synthesized compounds with the active structural analogs 4-hydroxy-2-oxo-1,2-dihydroquinoline-3 and 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxamides studied before.
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