4-Hydroxy-2-quinolones 148. Synthesis and antitubercular activity of 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid N-R-amides

被引：0

作者：

I. V. Ukrainets

A. A. Tkach

L. A. Grinevich

机构：

[1] National University of Pharmacy,

来源：

Chemistry of Heterocyclic Compounds | 2008年 / 44卷

关键词：

hetarylamides; 4-hydroxy-2-oxoquinoline-3-carboxylic acids; amidation; antitubercular activity; X-ray structural analysis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An improved method for the preparation of ethyl 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate has been proposed and a series of hetarylamides has been synthesized from it. A comparative analysis has been carried out of the antitubercular activities of the synthesized compounds with the active structural analogs 4-hydroxy-2-oxo-1,2-dihydroquinoline-3 and 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxamides studied before.

引用

共 50 条

[1] 4-HYDROXY-2-QUINOLONES 148. SYNTHESIS AND ANTI-TUBERCULAR ACTIVITY OF 1-HYDROXY-3-OXO-6,7-DIHYDRO-3H,5H-PYRIDO[3,2,1-ij]QUINOLINE-2-CARBOXYLIC ACID N-R-AMIDES
Ukrainets, I. V.
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Grinevich, L. A.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2008, 44 (08) : 956 - 966
[2] 4-hydroxy-2-quinolones. 108. N-R-amides of 9-fluoro-1-hydroxy-5-methyl-3- oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid and their antitubercular activity
Ukrainets I.V.
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[3] 4-Hydroxy-2-quinolones. 194*. 1-Hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid alkylamides. Synthesis, structure, and biological properties
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[4] 4-HYDROXY-2-QUINOLONES. 194. 1-HYDROXY-3-OXO-6,7-DIHYDRO-3H,5H-PYRIDO[3,2,1-ij]QUINOLINE-2-CARBOXYLIC ACID ALKYLAMIDES. SYNTHESIS, STRUCTURE, AND BIOLOGICAL PROPERTIES
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CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2011, 46 (12) : 1459 - 1466
[5] 4-hydroxy-2-quinolones.: 108.: N-R-amides of 9-fluoro-1-hydroxy-5-methyl-3-oxo-6,7-dihydro-3H,5H-pyrido-[3,2,1-ij]quinoline-2-carboxylic acid and their antituberculotic activity
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[6] 4-Hydroxy-2-quinolones 121. Synthesis and biological properties of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid alkylamides
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[7] 4-Hydroxy-2-quinolones. 122. Hetaryl amides of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid - Potential antituberculosis agents
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[8] 4-Hydroxy-2-quinolones 126. 1-Hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1- ij]quinoline-2-carboxylic acid hydrazide and its derivatives
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[9] 4-hydroxy-2-quinolones.: 126.: Hydrazide of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid and its derivatives
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[10] 4-Hydroxy-2-Quinolones. 233*. Synthesis and Diuretic Activity of 9-Bromo-7-Hydroxy-5-Oxo-2,3-Dihydro-1H,5H-Pyrido[3,2,1-ij]Quinoline-6-Carboxylic Acid Anilides
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