A receptor for green tea polyphenol EGCG

被引：0
|
作者：
Hirofumi Tachibana
Kiyoshi Koga
Yoshinori Fujimura
Koji Yamada
机构：
[1] Faculty of Agriculture,Department of Bioscience and Biotechnology
[2] Kyushu University,undefined
[3] Hakozaki 6-10-1,undefined
来源：
Nature Structural & Molecular Biology | 2004年 / 11卷
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摘要：
The major polyphenol in green tea, (−)-epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar Kd value.
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页码：380 / 381
页数：1
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