67-kDa Laminin Receptor Mediates the Beneficial Effects of Green Tea Polyphenol EGCG

Purpose of Review: Green tea is one of the most consumed beverages in the world. Through in vivo models and clinical trials, several studies have shown the beneficial effects of green tea. Epidemiological studies have revealed that green tea consumption is negatively correlated with the risk of cardiovascular diseases, stroke and cancer; however, little is known about the underlying molecular mechanisms. Recent Findings: (−)-Epigallocatechin-3-O-gallate (EGCG) is one of the major bioactive compounds in green tea, and several studies emphasise its central role in the beneficial effects of green tea. It has been demonstrated that the 67-kDa laminin receptor, a non-integrin laminin receptor, mediates the beneficial effects of EGCG through cyclic guanosine monophosphate–dependent mechanisms. Summary: In this review, we showed the role of 67LR as the sensor of the EGCG and its downstream cascade, and this review provides the recent findings in the mechanism of the beneficial effect of EGCG. © 2020, Springer Nature Switzerland AG.