Isolation and characterization of a novel oligomeric proanthocyanidin with significant anti-cancer activities from grape stems (Vitis vinifera)

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作者：
Kawahara Sei-ichi
Kazuya Toda
Kiriko Matsumoto
Chisato Ishihara
Shuhei Nonobe
Chisato Matsunaga
Yoshika K. Gomi
Shogo Senga
Koichiro Kawaguchi
Ayaka Yamamoto
Jutalak Suwannachot
Reiko Noda
Shuhei Kobayashi
Yasunori Hamauzu
Hidefumi Makabe
Hiroshi Fujii
机构：
[1] Shinshu University,Interdisciplinary Graduate School of Science and Technology
[2] 1260 Imogawa,St. Cousair Co., Ltd.
[3] Kami-minochi,Department of Bioscience and Biotechnology, Faculty of Agriculture
[4] Shinshu University,Graduate School of Science and Technology, Department of Biomedical Engineering
[5] Shinshu University,Graduate School of Science and Technology, Department of Agriculture, Division of Food Science and Biotechnology
[6] Shinshu University,Department of Interdisciplinary Genome Sciences and Cell Metabolism, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research
[7] Shinshu University,undefined
[8] Minami-minowa,undefined
来源：
Scientific Reports | / 9卷
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摘要：
Novel proanthocyanidin fractions from grape stem extracts were purified using Amberlite XAD-1180N, Sephadex-LH-20, Toyopearl HW40F and reverse phase high-performance liquid chromatography. Two key compounds were estimated as epigallocatechin-(epicatechin)7 gallate using electron-spray ionization time-of-flight mass spectrometry. Epigallocatechin-(epicatechin)7 gallate (compound 1) showed significant anti-cancer activity in PC-3 prostate cancer cells. In particular, compound 1 suppressed the gene expression of fatty acid-binding protein 5 (FABP5), which is involved in promoting cell proliferation and metastasis in prostate cancer cells.
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