Identification and characterization of oligomeric proanthocyanidins with significant anti-cancer activity in adzuki beans (Vigna angularis)

被引：22
|
作者：
Kawahara, Sei-ichi [1 ]
Ishihara, Chisato [2 ]
Matsumoto, Kiriko [3 ]
Senga, Shogo [1 ]
Kawaguchi, Koichiro [1 ]
Yamamoto, Ayaka [2 ]
Suwannachot, Jutalak [4 ]
Hamauzu, Yasunori [1 ,4 ]
Makabe, Hidefumi [1 ,4 ,5 ]
Fujii, Hiroshi [1 ,2 ,5 ]
机构：
[1] Shinshu Univ, Interdisciplinary Grad Sch Sci & Technol, 8304 Minami Minowa Kami Ina, Nagano 3994598, Japan
[2] Shinshu Univ, Grad Sch Sci & Technol, Dept Biomed Engn, 8304 Minami Minowa Kami Ina, Nagano 3994598, Japan
[3] Shinshu Univ, Fac Agr, Dept Biosci & Biotechnol, 8304 Minami Minowa Kami Ina, Nagano 3994598, Japan
[4] Shinshu Univ, Grad Sch Sci & Technol, Dept Agr, Div Food Sci & Biotechnol, 8304 Minami Minowa Kami Ina, Nagano 3994598, Japan
[5] Shinshu Univ, Inst Biomed Sci, Dept Biomol Innovat, Interdisciplinary Cluster Cutting Edge Res, Nagano 3994598, Japan
来源：
HELIYON | 2019年 / 5卷 / 10期
关键词：
Analytical chemistry; Food composition; Food chemistry; Biochemistry; Cancer research; Vigna angularis; Proanthocyanidin; Anti-cancer; Fatty acid-binding protein; ACID-BINDING PROTEIN; CELL-GROWTH; PROCYANIDINS; CANCER; EXPRESSION;
D O I：
10.1016/j.heliyon.2019.e02610
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The aim of the present study was to characterize and evaluate the anti-cancer activity of proanthocyanidin-enriched fractions from adzuki beans. For this purpose, we concentrated proanthocyanidins from adzuki beans (Vigna angularis) into five fractions using Amberlite XAD-1180N, Toyopearl HW40F, and Sepacore C-18 reverse-phase flash column chromatography. Proanthocyanidin-enriched fractions were characterized as (epi)catechin hexamer, heptamer, and octamer, epigallocatechin-(epi)catechin pentamer, and epigallocatechin-(epi)catechin hexamer using electrospray ionization time-of-flight mass spectrometry and thiolytic degradation. These fractions showed significant anti-cancer activity against the human PC-3 prostate cancer cell line. They also significantly suppressed the expression of the fatty acid-binding protein 5 gene, which plays critical roles in cell growth and metastasis in prostate cancer.
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页数：8
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