Mesenchymal stem cell-based therapy for ischemic stroke

被引：0

作者：

Anderson J.D. ^{[1
,11
]}

Pham M.T. ^{[1
]}

Contreras Z. ^{[1
]}

Hoon M. ^{[1
]}

Fink K.D. ^{[1
]}

Johansson H.J. ^{[2
]}

Rossignol J. ^{[3
]}

Dunbar G.L. ^{[3
]}

Showalter M. ^{[4
]}

Fiehn O. ^{[4
,5
]}

Bramlett C.S. ^{[1
]}

Bardini R.L. ^{[1
]}

Bauer G. ^{[1
]}

Fury B. ^{[1
]}

Hendrix K.J. ^{[1
]}

Chedin F. ^{[6
]}

El-Andaloussi S. ^{[7
,8
,9
]}

Hwang B. ^{[10
]}

Mulligan M.S. ^{[10
]}

Lehtiö J. ^{[2
]}

Nolta J.A. ^{[1
]}

机构：

[1] Department of Internal Medicine, Stem Cell Program, University of California Davis, Davis

[2] Department of Oncology-Pathology, Karolinska Institutet, Cancer Proteomics, Davis

[3] College of Medicine, Central Michigan University, Mt Pleasant

[4] West Coast Metabolomics Center, University of California, Davis

[5] Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah

[6] Department of Molecular and Cellular Biology, University of California Davis, Davis

[7] Department of Laboratory Medicine, Karolinska Institutet, Stockholm

[8] Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford

[9] Department of Surgery, University of Washington, Seattle

[10] Department of Surgery, Center for Lung Biology, University of Washington, Seattle

[11] Institute for Regenerative Cures, University of California Davis Medical Center, 2921 Stockton Blvd, Sacramento, 95817, CA

来源：

Chinese Neurosurgical Journal | / 2卷 / 1期

关键词：

Exosomes; Ischemic stroke; Mesenchymal stem cells;

D O I：

10.1186/s41016-016-0053-4

中图分类号：

学科分类号：

摘要：

Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available. Most currently approved treatments for ischemic stroke have narrow therapeutic windows, severely limiting the number of patients able to be treated. Mesenchymal stem cells represent a promising novel treatment for ischemic stroke. Numerous studies have demonstrated that mesenchymal stem cells functionally improve outcomes in rodent models of ischemic stroke. Recent studies have also shown that exosomes secreted by mesenchymal stem cells mediate much of this effect. In the present review, we summarize the current literature on the use of mesenchymal stem cells to treat ischemic stroke. Further studies investigating the mechanisms underlying mesenchymal stem cells tissue healing effects are warranted and would be of benefit to the field. © 2016 The Author(s).

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