Epstein–Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of One Case and Review of the Literature

被引:0
|
作者
Zhenjian Cai
Mei Lin
Angel I. Blanco
Jing Liu
Hui Zhu
机构
[1] The University of Texas Health Science Center at Houston,Department of Pathology and Laboratory Medicine
[2] The University of Texas Health Science Center at Houston,Radiation Oncology and Gamma Knife Center, Memorial Herman Hospital
来源
Head and Neck Pathology | 2019年 / 13卷
关键词
Epstein–Barr virus; Nasopharynx; Neuroendocrine carcinoma; Nasopharyngeal carcinoma;
D O I
暂无
中图分类号
学科分类号
摘要
Epstein–Barr Virus (EBV)-positive neuroendocrine carcinoma (NEC) of the nasopharynx is exceedingly rare, only two cases have been reported in the literature. While EBV infection is strongly associated with nasopharyngeal carcinoma, which is carcinoma with squamous differentiation, the link between EBV and NEC is not well known, and can be diagnostically challenging. In this study, we report the third case of EBV-positive large cell NEC of nasopharynx with neck lymph node metastasis. The patient was treated with combined radiation and chemotherapy and showed complete clinical and radiological response. Similar treatment response has been reported in another patient with high stage EBV-positive large cell NEC, suggesting that EBV status is an important prognostic factor. Recognition of this rare tumor is important for disease management and patient prognosis. We also review the literature about the clinical and pathologic presentation of neuroendocrine tumors of nasopharynx.
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页码:313 / 317
页数:4
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