pH-sensitive biopolymeric hydrogel-based on indole-3-acetic acid for wound healing and anti-cancer applications

Gold nanoparticles (AuNPs) are widely used and important nanomaterials and combine with hydrogels to design novel nanocomposite hydrogels. An emerging approach to strengthen the polymeric hydrogels and to include multiple functionalities focuses on incorporating nanoparticles within the hydrogel network. This present investigation focused on the most recent developments in the field of nanocomposite hydrogels with emphasis on biomedical applications. The pH-responsive nanocomposite hydrogels based on indole-3-acetic acid (IAA), which has extracted from leaf of Stachytarpheta jamaicensis, citric acid, diethylene glycol and colloidal gold nanoparticles. The obtained nanocomposite hydrogels found to have desired surface morphology and enhanced pH-sensitive swelling and thermal stability. The resultant nanocomposite hydrogels may be recommended for biomedical applications mere in future such as pH-sensitive drug delivery, wound healing application, anti cancer, antimicrobial material, antioxidant, cytotoxicity with more than 80% cell viability and nanomedicine.