Economic Impact and Long-Term Graft Outcomes of Mycophenolate Mofetil Dosage Modifications Following Gastrointestinal Complications in Renal Transplant Recipients

被引:0
|
作者
Gerardo Machnicki
Jean-Francois Ricci
Daniel C. Brennan
Mark A. Schnitzler
机构
[1] Novartis Pharmaceuticals,Department of Medicine
[2] Novartis Pharma AG,Center for Outcomes Research
[3] Washington University School of Medicine,undefined
[4] Saint Louis University School of Medicine,undefined
[5] Saint Louis University School of Medicine (SLUCOR),undefined
来源
PharmacoEconomics | 2008年 / 26卷
关键词
Graft Failure; Mycophenolate Mofetil; Graft Loss; United States Renal Data System; Functioning Graft;
D O I
暂无
中图分类号
学科分类号
摘要
Introduction: Gastrointestinal (GI) complications are common following renal transplantation. Discontinuing or reducing the dosage of mycophenolate mofetil can improve GI tolerability but adversely affect graft outcomes. This analysis was undertaken to assess the 3-year economic and clinical impact of mycophenolate mofetil dosage modifications or discontinuation following post-transplant GI events compared with no dosage modification.
引用
收藏
页码:951 / 967
页数:16
相关论文
共 50 条
  • [1] Economic Impact and Long-Term Graft Outcomes of Mycophenolate Mofetil Dosage Modifications Following Gastrointestinal Complications in Renal Transplant Recipients
    Machnicki, Gerardo
    Ricci, Jean-Francois
    Brennan, Daniel C.
    Schnitzler, Mark A.
    [J]. PHARMACOECONOMICS, 2008, 26 (11) : 951 - 967
  • [2] Long-term outcome of gastrointestinal complications in renal transplant patients treated with mycophenolate mofetil
    Hardinger, KL
    Brennan, DC
    Lowell, J
    Schnitzler, MA
    [J]. TRANSPLANT INTERNATIONAL, 2004, 17 (10) : 609 - 616
  • [3] Effect of mycophenolate mofetil on long-term outcomes in African American renal transplant recipients
    Meier-Kriesche, HU
    Ojo, AO
    Leichtman, AB
    Punch, JD
    Hanson, JA
    Cibrik, DM
    Kaplan, B
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2000, 11 (12): : 2366 - 2370
  • [4] Improvement in long-term graft survival in cadaveric renal transplant recipients treated with mycophenolate mofetil
    Hazzan, M
    Provot, F
    Glowacki, F
    Copin, MC
    Roumilhac, D
    Labalette, M
    Pruvot, F
    Noel, C
    [J]. TRANSPLANT INTERNATIONAL, 2004, 17 (09) : 525 - 530
  • [5] Impact of mycophenolate mofetil (MMF)-related gastrointestinal complications and MMF dose alterations on transplant outcomes and healthcare costs in renal transplant recipients
    Tierce, JC
    Porterfield-Baxa, J
    Petrilla, AA
    Kilburg, A
    Ferguson, RM
    [J]. CLINICAL TRANSPLANTATION, 2005, 19 (06) : 779 - 784
  • [6] Graft loss and costs following gastrointestinal (GI) complications and GI medication use in renal transplant recipients using mycophenolate mofetil (MMF)
    Lalla, Anjana
    Gilmore, Amanda
    Machnicki, Gerardo
    Legorreta, Antonio
    [J]. PHARMACY WORLD & SCIENCE, 2007, 29 (05): : 440 - 440
  • [7] Long-term pharmacokinetics of mycophenolate mofetil (MF) suspension in pediatric renal transplant recipients.
    Weber, LT
    Hoecker, B
    Bunchman, T
    Rashford, M
    Toenshoff, B
    [J]. PEDIATRIC TRANSPLANTATION, 2005, 9 : 66 - 66
  • [8] Linking gastrointestinal events, mycophenolate mofetil dose reduction and discontinuation, graft outcomes, and healthcare costs in renal transplant recipients
    Legorreta, Antonio P.
    Kang, Ning
    Robinson, Matthew L.
    Balp, Maria Magdalena
    Machnicki, Gerardo
    Marehbian, Josh
    Gilmore, Amanda S.
    [J]. TRANSPLANT INTERNATIONAL, 2007, 20 : 136 - 136
  • [9] Long-Term Mycophenolate Mofetil Treatment in Pediatric Renal Transplant Patients
    Roberts, John P.
    Potter, Donald
    Bouw, M. Rene
    [J]. DIALYSIS & TRANSPLANTATION, 2009, 38 (11) : 445 - +
  • [10] The impact of mycophenolate mofetil on long-term outcomes in kidney transplantation
    Srinivas, TR
    Kaplan, B
    Schold, JD
    Meier-Kriesche, HU
    [J]. TRANSPLANTATION, 2005, 80 (02) : S211 - S220