Synthesis and antimicrobial studies of azomethine and N-arylamine derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-methicillin-resistant Staphylococcus aureus agents

被引：0
|
作者：
Jamarcus Brider
Trent Rowe
Danielle Jamie Gibler
Adam Gottsponer
Evan Delancey
Michael Drew Branscum
Allyn Ontko
David Gilmore
Mohammad A. Alam
机构：
[1] College of Science and Mathematics,Department of Chemistry and Physics
[2] Arkansas State University,Department of Biological Sciences
[3] College of Science and Mathematics,undefined
[4] Arkansas State University,undefined
来源：
Medicinal Chemistry Research | 2016年 / 25卷
关键词：
Pyrazole; Antimicrobials; Resistant; Imines; N-aryl amines; Antibacterial; Methicillin-resistant;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Antimicrobial resistance to antibiotics is a global concern. Without urgent and coordinated action, the world is moving towards a post-antibiotic era, in which normal infections or minor injuries may become fatal. In an effort to find new agents to combat this resistance, we report the synthesis and antimicrobial activities of 1,3-diphenyl pyrazole derivatives. Several compounds have shown growth inhibition up to 24 mm in size against Staphylococcus aureus inhibition studies. We tested the active compounds against methicillin-resistant Staphylococcus aureus in minimum inhibitory concentration tests and found activity as low as 16 μg/mL.[inline-graphic not available: see fulltext]
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页码：2691 / 2697
页数：6
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