Genetic architecture of artemisinin-resistant Plasmodium falciparum

被引：0

作者：

Olivo Miotto

Roberto Amato

Elizabeth A Ashley

Bronwyn MacInnis

Jacob Almagro-Garcia

Chanaki Amaratunga

Pharath Lim

Daniel Mead

Samuel O Oyola

Mehul Dhorda

Mallika Imwong

Charles Woodrow

Magnus Manske

Jim Stalker

Eleanor Drury

Susana Campino

Lucas Amenga-Etego

Thuy-Nhien Nguyen Thanh

Hien Tinh Tran

Pascal Ringwald

Delia Bethell

Francois Nosten

Aung Pyae Phyo

Sasithon Pukrittayakamee

Kesinee Chotivanich

Char Meng Chuor

Chea Nguon

Seila Suon

Sokunthea Sreng

Paul N Newton

Mayfong Mayxay

Maniphone Khanthavong

Bouasy Hongvanthong

Ye Htut

Kay Thwe Han

Myat Phone Kyaw

Md Abul Faiz

Caterina I Fanello

Marie Onyamboko

Olugbenga A Mokuolu

Christopher G Jacob

Shannon Takala-Harrison

Christopher V Plowe

Nicholas P Day

Arjen M Dondorp

Chris C A Spencer

Gilean McVean

Rick M Fairhurst

Nicholas J White

Dominic P Kwiatkowski

机构：

[1] Wellcome Trust Sanger Institute,Nuffield Department of Medicine

[2] Medical Research Council (MRC) Centre for Genomics and Global Health,Department of Immunology and Medicine

[3] University of Oxford,Department of Medical Research

[4] Mahidol-Oxford Tropical Medicine Research Unit,Department of Paediatrics and Child Health

[5] Faculty of Tropical Medicine,Department of Statistics

[6] Mahidol University,undefined

[7] Wellcome Trust Centre for Human Genetics,undefined

[8] University of Oxford,undefined

[9] Centre for Tropical Medicine,undefined

[10] University of Oxford,undefined

[11] Laboratory of Malaria and Vector Research,undefined

[12] National Institute of Allergy and Infectious Diseases,undefined

[13] US National Institutes of Health,undefined

[14] National Center for Parasitology,undefined

[15] Entomology and Malaria Control,undefined

[16] Center for Vaccine Development,undefined

[17] University of Maryland School of Medicine,undefined

[18] WorldWide Antimalarial Resistance Network (WWARN),undefined

[19] Asia Regional Centre,undefined

[20] Mahidol University,undefined

[21] Faculty of Tropical Medicine,undefined

[22] Mahidol University,undefined

[23] Navrongo Health Research Centre,undefined

[24] Oxford University Clinical Research Unit,undefined

[25] Wellcome Trust Major Overseas Programme,undefined

[26] Global Malaria Programme,undefined

[27] World Health Organization,undefined

[28] US Army Medical Component,undefined

[29] Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS),undefined

[30] Shoklo Malaria Research Unit,undefined

[31] Mahidol-Oxford Tropical Medicine Research Unit,undefined

[32] Faculty of Tropical Medicine,undefined

[33] Mahidol University,undefined

[34] Lao Oxford Mahosot Wellcome Trust Research Unit (LOMWRU),undefined

[35] Mahosot Hospital,undefined

[36] Faculty of Postgraduate Studies,undefined

[37] University of Health Sciences,undefined

[38] Center of Malariology,undefined

[39] Parasitology and Entomology,undefined

[40] Ministry of Health,undefined

[41] Lower Myanmar,undefined

[42] Malaria Research Group and Dev Care Foundation,undefined

[43] Kinshasa School of Public Health,undefined

[44] University of Ilorin,undefined

[45] Howard Hughes Medical Institute,undefined

[46] University of Maryland School of Medicine,undefined

[47] University of Oxford,undefined

来源：

Nature Genetics | 2015年 / 47卷

关键词：

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中图分类号：

学科分类号：

摘要：

Dominic Kwiatkowski and colleagues report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin. They identify markers of a genetic background on which kelch13 mutations conferring artemisinin resistance are likely to emerge.

引用

页码：226 / 234

页数：8

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