Genetic architecture of artemisinin-resistant Plasmodium falciparum

被引：0

作者：

Olivo Miotto

Roberto Amato

Elizabeth A Ashley

Bronwyn MacInnis

Jacob Almagro-Garcia

Chanaki Amaratunga

Pharath Lim

Daniel Mead

Samuel O Oyola

Mehul Dhorda

Mallika Imwong

Charles Woodrow

Magnus Manske

Jim Stalker

Eleanor Drury

Susana Campino

Lucas Amenga-Etego

Thuy-Nhien Nguyen Thanh

Hien Tinh Tran

Pascal Ringwald

Delia Bethell

Francois Nosten

Aung Pyae Phyo

Sasithon Pukrittayakamee

Kesinee Chotivanich

Char Meng Chuor

Chea Nguon

Seila Suon

Sokunthea Sreng

Paul N Newton

Mayfong Mayxay

Maniphone Khanthavong

Bouasy Hongvanthong

Ye Htut

Kay Thwe Han

Myat Phone Kyaw

Md Abul Faiz

Caterina I Fanello

Marie Onyamboko

Olugbenga A Mokuolu

Christopher G Jacob

Shannon Takala-Harrison

Christopher V Plowe

Nicholas P Day

Arjen M Dondorp

Chris C A Spencer

Gilean McVean

Rick M Fairhurst

Nicholas J White

Dominic P Kwiatkowski

机构：

[1] Wellcome Trust Sanger Institute,Nuffield Department of Medicine

[2] Medical Research Council (MRC) Centre for Genomics and Global Health,Department of Immunology and Medicine

[3] University of Oxford,Department of Medical Research

[4] Mahidol-Oxford Tropical Medicine Research Unit,Department of Paediatrics and Child Health

[5] Faculty of Tropical Medicine,Department of Statistics

[6] Mahidol University,undefined

[7] Wellcome Trust Centre for Human Genetics,undefined

[8] University of Oxford,undefined

[9] Centre for Tropical Medicine,undefined

[10] University of Oxford,undefined

[11] Laboratory of Malaria and Vector Research,undefined

[12] National Institute of Allergy and Infectious Diseases,undefined

[13] US National Institutes of Health,undefined

[14] National Center for Parasitology,undefined

[15] Entomology and Malaria Control,undefined

[16] Center for Vaccine Development,undefined

[17] University of Maryland School of Medicine,undefined

[18] WorldWide Antimalarial Resistance Network (WWARN),undefined

[19] Asia Regional Centre,undefined

[20] Mahidol University,undefined

[21] Faculty of Tropical Medicine,undefined

[22] Mahidol University,undefined

[23] Navrongo Health Research Centre,undefined

[24] Oxford University Clinical Research Unit,undefined

[25] Wellcome Trust Major Overseas Programme,undefined

[26] Global Malaria Programme,undefined

[27] World Health Organization,undefined

[28] US Army Medical Component,undefined

[29] Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS),undefined

[30] Shoklo Malaria Research Unit,undefined

[31] Mahidol-Oxford Tropical Medicine Research Unit,undefined

[32] Faculty of Tropical Medicine,undefined

[33] Mahidol University,undefined

[34] Lao Oxford Mahosot Wellcome Trust Research Unit (LOMWRU),undefined

[35] Mahosot Hospital,undefined

[36] Faculty of Postgraduate Studies,undefined

[37] University of Health Sciences,undefined

[38] Center of Malariology,undefined

[39] Parasitology and Entomology,undefined

[40] Ministry of Health,undefined

[41] Lower Myanmar,undefined

[42] Malaria Research Group and Dev Care Foundation,undefined

[43] Kinshasa School of Public Health,undefined

[44] University of Ilorin,undefined

[45] Howard Hughes Medical Institute,undefined

[46] University of Maryland School of Medicine,undefined

[47] University of Oxford,undefined

来源：

Nature Genetics | 2015年 / 47卷

关键词：

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中图分类号：

学科分类号：

摘要：

Dominic Kwiatkowski and colleagues report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin. They identify markers of a genetic background on which kelch13 mutations conferring artemisinin resistance are likely to emerge.

引用

页码：226 / 234

页数：8

共 50 条

[1] Genetic architecture of artemisinin-resistant Plasmodium falciparum
Miotto, Olivo
Amato, Roberto
Ashley, Elizabeth A.
MacInnis, Bronwyn
Almagro-Garcia, Jacob
Amaratunga, Chanaki
Lim, Pharath
Mead, Daniel
Oyolal, Samuel O.
Dhorda, Mehul
Imwong, Mallika
Woodrow, Charles
Manske, Magnus
Stalker, Jim
Drury, Eleanor
Campino, Susana
Amenga-Etego, Lucas
Thuy-Nhien Nguyen Thanh
Hien Tinh Tran
Ringwald, Pascal
Bethellm, Delia
Nosten, Francois
Phyo, Aung Pyae
Pukrittayakamee, Sasithon
Chotivanich, Kesinee
Chuor, Char Meng
Nguon, Chea
Suon, Seila
Sreng, Sokunthea
Newton, Paul N.
Mayxay, Mayfong
Khanthavong, Maniphone
Hongvanthong, Bouasy
Htut, Ye
Han, Kay Thwe
Kyaw, Myat Phone
Faiz, Md Abul
Fanello, Caterina I.
Onyamboko, Marie
Mokuolu, Olugbenga A.
Jacob, Christopher G.
Takala-Harrison, Shannon
Plowe, Christopher V.
Day, Nicholas P.
Dondorp, Arjen M.
Spencer, Chris C. A.
McVean, Gilean
Fairhurst, Rick M.
White, Nicholas J.
Kwiatkowski, Dominic P.
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[4] Laboratory Detection of Artemisinin-Resistant Plasmodium falciparum
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[6] Artemisinin-Resistant Plasmodium falciparum in Africa REPLY
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[7] Emergence of Indigenous Artemisinin-Resistant Plasmodium falciparum in Africa
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[8] A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
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[J]. NATURE, 2014, 505 (7481) : 50 - +
[9] Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
Miotto, Olivo
Almagro-Garcia, Jacob
Manske, Magnus
MacInnis, Bronwyn
Campino, Susana
Rockett, Kirk A.
Amaratunga, Chanaki
Lim, Pharath
Suon, Seila
Sreng, Sokunthea
Anderson, Jennifer M.
Duong, Socheat
Nguon, Chea
Chuor, Char Meng
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Se, Youry
Lon, Chantap
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Su, Xin-zhuan
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[10] More on Artemisinin-Resistant Plasmodium falciparum in Eastern India
Rasmussen, Charlotte
Valecha, Neena
Ringwald, Pascal
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (11): : E14 - E14

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