L-Myc expression by dendritic cells is required for optimal T-cell priming

被引：0

作者：

Wumesh KC

Ansuman T. Satpathy

Aaron S. Rapaport

Carlos G. Briseño

Xiaodi Wu

Jörn C. Albring

Emilie V. Russler-Germain

Nicole M. Kretzer

Vivek Durai

Stephen P. Persaud

Brian T. Edelson

Jakob Loschko

Marina Cella

Paul M. Allen

Michel C. Nussenzweig

Marco Colonna

Barry P. Sleckman

Theresa L. Murphy

Kenneth M. Murphy

机构：

[1] Washington University School of Medicine,Department of Pathology and Immunology

[2] 660 S. Euclid Avenue,Department of Medicine A

[3] St Louis,undefined

[4] Missouri 63110,undefined

[5] USA,undefined

[6] Hematology and Oncology,undefined

[7] University of Muenster,undefined

[8] 48149 Muenster,undefined

[9] Germany,undefined

[10] Laboratory of Molecular Immunology,undefined

[11] Howard Hughes Medical Institute,undefined

[12] The Rockefeller University,undefined

[13] Howard Hughes Medical Institute,undefined

[14] Washington University School of Medicine,undefined

[15] 660 S. Euclid Avenue,undefined

[16] St Louis,undefined

[17] Missouri 63110,undefined

[18] USA,undefined

来源：

Nature | 2014年 / 507卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

L-Myc, a paralogue of the proto-oncogene c-Myc, is shown to regulate dendritic cell homeostasis and functionality; unlike c-Myc, L-Myc is not repressed by interferons and its expression allows for optimal dendritic cell proliferation and T-cell priming in the presence of inflammation.

引用

页码：243 / 247

页数：4

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